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Descriptor English: WAP Four-Disulfide Core Domain Protein 2
Descriptor Spanish: Proteína 2 de Dominio del Núcleo de Cuatro Disulfuros WAP
Descriptor proteína de dominio central de cuatro disulfuros WAP de tipo 2
Entry term(s) proteína WFDC2
proteína secretora epididimal E4
proteína secretora epididimaria E4
Scope note: Glicoproteína secretada de 25 kDa, miembro de la familia de seroproteínas ácidas (WAP) con dominio central de cuatro disulfuros (WFDC), con expresión tisular específica en el EPIDÍDIMO. También se expresa en un número limitado de otros órganos tales como el aparato reproductor femenino, el tejido mamario, el riñón, regiones de las vías respiratorias y la nasofaringe. La proteína es un biomarcador del cáncer ovárico epitelial.
Descriptor Portuguese: Proteína 2 do Domínio Central WAP de Quatro Dissulfetos
Descriptor French: Protéine-2 à domaine WAP à 4 ponts disulfure
Entry term(s): Epididymal Secretory Protein E4
Protein, WFDC2
WAP Four Disulfide Core Domain Protein 2
WFDC2 Protein
Tree number(s): D12.776.298.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000081102
Scope note: A secreted 25-kDa glycoprotein member of the Whey-acidic-protein (WAP) four-disulfide core (WFDC) domain family with tissue specific expression in the EPIDIDYMIS. It is also expressed in a limited number of other organs which include female reproductive tract, breast tissue, kidney, regions of the respiratory tract and nasopharynx. The protein is a biomarker for epithelial ovarian cancer.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
Public MeSH Note: 2020
History Note: 2020
DeCS ID: 59270
Unique ID: D000081102
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2020/01/01
Date of Entry: 2019/07/08
Revision Date: 2019/08/01
WAP Four-Disulfide Core Domain Protein 2 - Preferred
Concept UI M000649709
Scope note A secreted 25-kDa glycoprotein member of the Whey-acidic-protein (WAP) four-disulfide core (WFDC) domain family with tissue specific expression in the EPIDIDYMIS. It is also expressed in a limited number of other organs which include female reproductive tract, breast tissue, kidney, regions of the respiratory tract and nasopharynx. The protein is a biomarker for epithelial ovarian cancer.
Preferred term WAP Four-Disulfide Core Domain Protein 2
Entry term(s) Epididymal Secretory Protein E4
Protein, WFDC2
WAP Four Disulfide Core Domain Protein 2
WFDC2 Protein



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