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Descriptor English: Globosides
Descriptor Spanish: Globósidos
Descriptor globósidos
Entry term(s) citolipinas
lacto-N-neotetraosilceramida
lacto-N-tetraosilceramida
Scope note: Glucoesfingolípidos que contienen N-acetilglucosamina (paraglobósido) o N-acetilgalactosamina (globósido). El globósido es el antígeno P del eritrocito, mientras que el paraglobósido es un intermediario en la biosíntesis del grupo sanguíneo ABH y antígenos glucoesfingolípidos P1. La acumulación de globósido en los tejido, debido a un defecto de las hexosaminidasas A y B, es la causa de la enfermedad de Sandhoff.
Descriptor Portuguese: Globosídeos
Descriptor French: Globosides
Entry term(s): Cytolipins
Lacto N neotetraosylceramide
Lacto N tetraosylceramide
Lacto-N-neotetraosylceramide
Lacto-N-tetraosylceramide
Lactoneotetraosylceramide
Tree number(s): D02.065.313.425
D09.400.410.420.525.200.425
D10.390.470.675.200.425
D10.570.877.360.612.200.425
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005915
Scope note: Glycosphingolipids containing N-acetylglucosamine (paragloboside) or N-acetylgalactosamine (globoside). Globoside is the P antigen on erythrocytes and paragloboside is an intermediate in the biosynthesis of erythrocyte blood group ABH and P 1 glycosphingolipid antigens. The accumulation of globoside in tissue, due to a defect in hexosaminidases A and B, is the cause of Sandhoff disease.
Annotation: /biosyn /physiol permitted
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Cerebrosides (1972-1978)
Glycolipids (1966-1978)
Glycosphingolipids (1975-1978)
Public MeSH Note: 91; was see under GLYCOSPHINGOLIPIDS 1979-90
History Note: 91(79); was see under GLYCOSPHINGOLIPIDS 1979-90
DeCS ID: 6060
Unique ID: D005915
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1978/05/16
Revision Date: 2006/07/05
Globosides - Preferred
Concept UI M0009291
Scope note Glycosphingolipids containing N-acetylglucosamine (paragloboside) or N-acetylgalactosamine (globoside). Globoside is the P antigen on erythrocytes and paragloboside is an intermediate in the biosynthesis of erythrocyte blood group ABH and P 1 glycosphingolipid antigens. The accumulation of globoside in tissue, due to a defect in hexosaminidases A and B, is the cause of Sandhoff disease.
Preferred term Globosides
Cytolipins - Narrower
Concept UI M0009292
Preferred term Cytolipins
Entry term(s) Lacto N neotetraosylceramide
Lacto N tetraosylceramide
Lacto-N-neotetraosylceramide
Lacto-N-tetraosylceramide
Lactoneotetraosylceramide



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