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Descriptor English: Glucose-6-Phosphate Isomerase
Descriptor Spanish: Glucosa-6-Fosfato Isomerasa
Descriptor glucosa-6-fosfato isomerasa
Entry term(s) fosfoglucosa isomerasa
fosfohexosa isomerasa
glucosafosfato isomerasa
Scope note: Aldosa-cetosa isomerasa que cataliza la interconversión reversible de la glucosa-6-fosfato y de la fructosa-6-fosfato. En los organismos procariotas y eucariotas desempeña un papel esencial en las vías glicolítica y gluconeogénica. En los sistemas de los mamíferos la enzima se encuentra en el citoplasma y como proteína secretada. Se ha referido a esta forma secretada de glucosa-6-fosfato isomerasa como factor de motilidad autocrino o neuroleucina. y actúa como citocina que se une al RECEPTOR DEL FACTOR DE MOTILIDAD AUTOCRINO. La deficiencia de la enzima en los humanos es un rasgo autosómico recesivo que da lugar a ANEMIA HEMOLÍTICA CONGÉNITA NO ESFEROCÍTICA.
Descriptor Portuguese: Glucose-6-Fosfato Isomerase
Descriptor French: Glucose 6-phosphate isomerase
Entry term(s): Autocrine Motility Factor
Factor, Autocrine Motility
Glucose 6 Phosphate Isomerase
Glucosephosphate Isomerase
Isomerase, Glucose 6 Phosphate
Isomerase, Glucose-6-Phosphate
Isomerase, Glucosephosphate
Isomerase, Phosphoglucose
Isomerase, Phosphohexose
Motility Factor, Autocrine
Neuroleukin
Phosphoglucose Isomerase
Phosphohexose Isomerase
Tumor Autocrine Motility Factor
Tumor Cell Autocrine Motility Factor
Tumor-Cell Autocrine Motility Factor
Tree number(s): D08.811.399.475.200.350
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005956
Scope note: An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Anemia, Hemolytic, Congenital Nonspherocytic
deficiencia:Anemia Hemolítica Congénita no Esferocítica
deficiência:Anemia Hemolítica Congênita não Esferocítica
Registry Number: EC 5.3.1.9
CAS Type 1 Name: D-Glucose-6-phosphate ketol-isomerase
Public MeSH Note: 1998 (1965); see GLUCOSEPHOSPHATE ISOMERASE 1965-1997; for AUTOCRINE MOTILITY FACTOR see AUTOCRINE MOTILITY FACTOR 1992-2011; for NEUROLEUKIN see NEUROLEUKIN 1990-2011
History Note: 1998(1965)
DeCS ID: 6101
Unique ID: D005956
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2011/06/24
Glucose-6-Phosphate Isomerase - Preferred
Concept UI M0009354
Scope note An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Preferred term Glucose-6-Phosphate Isomerase
Entry term(s) Glucose 6 Phosphate Isomerase
Glucosephosphate Isomerase
Isomerase, Glucose 6 Phosphate
Isomerase, Glucose-6-Phosphate
Isomerase, Glucosephosphate
Isomerase, Phosphoglucose
Isomerase, Phosphohexose
Phosphoglucose Isomerase
Phosphohexose Isomerase
Autocrine Motility Factor - Narrower
Concept UI M0025255
Scope note A secreted form of glucose-6-phosphate isomerase.
Preferred term Autocrine Motility Factor
Entry term(s) Factor, Autocrine Motility
Motility Factor, Autocrine
Neuroleukin
Tumor Autocrine Motility Factor
Tumor Cell Autocrine Motility Factor
Tumor-Cell Autocrine Motility Factor



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