| Descriptor English: | Heavy Chain Disease | ||||||
| Descriptor Spanish: |
Enfermedad de las Cadenas Pesadas
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| Descriptor Portuguese: | Doença das Cadeias Pesadas | ||||||
| Descriptor French: | Maladie des chaines lourdes | ||||||
| Entry term(s): |
Franklin Disease Franklin's Disease Franklins Disease Heavy Chain Diseases gamma Chain Disease gamma-Chain Disease gamma-Chain Diseases mu Chain Disease mu-Chain Disease mu-Chain Diseases |
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| Tree number(s): |
C15.378.147.780.490 C15.604.515.435 C20.683.780.490 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D006362 | ||||||
| Scope note: | A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes. |
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| Annotation: | specify the immunoglobulin fragment coord NIM, as gamma chain dis = HEAVY CHAIN DISEASE (IM) + IMMUNOGLOBULIN GAMMA-CHAINS (NIM); ALPHA-CHAIN DISEASE see IMMUNOPROLIFERATIVE SMALL INTESTINAL DISEASE is available |
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| Allowable Qualifiers: |
BL blood CF cerebrospinal fluid CI chemically induced CL classification CN congenital CO complications DG diagnostic imaging DH diet therapy DI diagnosis DT drug therapy EC economics EH ethnology EM embryology EN enzymology EP epidemiology ET etiology GE genetics HI history IM immunology ME metabolism MI microbiology MO mortality NU nursing PA pathology PC prevention & control PP physiopathology PS parasitology PX psychology RH rehabilitation RT radiotherapy SU surgery TH therapy UR urine VE veterinary VI virology |
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| Public MeSH Note: | 66 |
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| History Note: | 66(64) |
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| Entry Version: | HEAVY CHAIN DIS |
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| Related: |
Immunoglobulin Heavy Chains
MeSH | ||||||
| DeCS ID: | 6512 | ||||||
| Unique ID: | D006362 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1966/01/01 | ||||||
| Date of Entry: | 1999/01/01 | ||||||
| Revision Date: | 2005/07/01 |
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|
Heavy Chain Disease
- Preferred
mu-Chain Disease
- Narrower
gamma-Chain Disease
- Related but not broader or narrower
| Concept UI |
M0009991 |
| Scope note | A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes. |
| Preferred term | Heavy Chain Disease |
| Entry term(s) |
Heavy Chain Diseases |
| Concept UI |
M0009993 |
| Preferred term | mu-Chain Disease |
| Entry term(s) |
mu Chain Disease mu-Chain Diseases |
| Concept UI |
M0009992 |
| Preferred term | gamma-Chain Disease |
| Entry term(s) |
Franklin Disease Franklin's Disease Franklins Disease gamma Chain Disease gamma-Chain Diseases |
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