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Descriptor English: Immunosuppressive Agents
Descriptor Spanish: Inmunosupresores
Descriptor inmunosupresores
Entry term(s) agente inmunosupresor
agentes inmunosupresores
fármacos inmunosupresores
inmunosupresor
Scope note: Fármacos que reducen la función inmunitaria mediante distintos mecanismos de acción. Los inmunosupresores citotóxicos clásicos actúan inhibiendo la síntesis de ADN. Otros pueden actuar activando los LINFOCITOS T o inhibiendo la activación de los LINFOCITOS T COOPERADORES. En el pasado, la inmunosupresión se llevaba a cabo principalmente para impedir el rechazo de los órganos trasplantados; hoy en día están apareciendo nuevas aplicaciones que implican la mediación de los efectos de las INTERLEUCINAS y de otras CITOCINAS.
Descriptor Portuguese: Imunossupressores
Descriptor French: Immunosuppresseurs
Entry term(s): Agent, Immunosuppressive
Agents, Immunosuppressive
Immunosuppressant
Immunosuppressants
Immunosuppressive Agent
Tree number(s): D27.505.696.477.656
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007166
Scope note: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Public MeSH Note: 66
History Note: 66(64)
Related: Antilymphocyte Serum MeSH
Antirheumatic Agents MeSH
DeCS ID: 7344
Unique ID: D007166
NLM Classification: QW 920
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27
Immunosuppressive Agents - Preferred
Concept UI M0011171
Scope note Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Preferred term Immunosuppressive Agents
Entry term(s) Agent, Immunosuppressive
Agents, Immunosuppressive
Immunosuppressant
Immunosuppressants
Immunosuppressive Agent



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