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Descriptor English: Keratins
Descriptor Spanish: Queratinas
Descriptor queratinas
Entry term(s) citoqueratina
proteína asociada a la queratina
Scope note: Clase de proteínas fibrosas o escleroproteínas que son el principal componente de la EPIDERMIS, el PELO, las UÑAS, los tejidos córneos y la matriz orgánica del ESMALTE dental. Se han identificado dos grupos conformacionales: la alfa-queratina, cuyo esqueleto peptídico constituye una estructura formada por dos hélices alfa paralelas enrolladas entre sí que conforma la QUERATINA DE TIPO I y la QUERATINA DE TIPO II; y la beta-queratina, cuyo esqueleto constituye una estructura en zigzag o en forma de hoja plegada. Las alfa-queratinas se han clasificado en al menos 20 subtipos. Ademas, debido a la DUPLICACIÓN GÉNICA, se han encontrado múltiples isoformas de los subtipos.
Descriptor Portuguese: Queratinas
Descriptor French: Kératines
Entry term(s): Associated Protein, Keratin
Cytokeratin
Keratin
Keratin Associated Protein
Keratin Associated Proteins
Keratin-Associated Proteins
Protein, Keratin Associated
alpha Keratin
alpha-Keratin
Tree number(s): D05.750.078.593.450
D12.776.220.475.450
D12.776.860.607
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007633
Scope note: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 68238-35-7
Public MeSH Note: 2007; see KERATIN 1966-2006; KERATIN-ASSOCIATED PROTEINS was indexed under KERATIN 2000-2006, & under PROTEINS 1993-1999
History Note: 2007(1966)
Related: Intermediate Filaments MeSH
Keratinocytes MeSH
DeCS ID: 7802
Unique ID: D007633
NLM Classification: QU 55.3
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27
Keratins - Preferred
Concept UI M0011957
Scope note A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Preferred term Keratins
Entry term(s) Cytokeratin
Keratin
Keratin-Associated Proteins - Narrower
Concept UI M0213667
Preferred term Keratin-Associated Proteins
Entry term(s) Associated Protein, Keratin
Keratin Associated Protein
Keratin Associated Proteins
Protein, Keratin Associated
alpha-Keratin - Narrower
Concept UI M0494274
Preferred term alpha-Keratin
Entry term(s) alpha Keratin



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