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Descriptor English: Methylmalonic Acid
Descriptor Spanish: Ácido Metilmalónico
Descriptor ácido metilmalónico
Scope note: Derivado del ácido malónico que es intermediario vital en el metabolismo de las grasas y de las proteínas. Las anomalías en el metabolismo del ácido metilmalónico llevan a aciduria metilmalónica. Se atribuye esta metabolopatía a un bloqueo en la conversión enzimática del metilmalonil CoA a succinil CoA.
Descriptor Portuguese: Ácido Metilmalônico
Descriptor French: Acide méthyl-malonique
Entry term(s): Acid, Methylmalonic
Tree number(s): D02.241.081.337.540.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008764
Scope note: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
Annotation: /biosyn /physiol permitted
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Registry Number: 8LL8S712J7
CAS Type 1 Name: Propanedioic acid, methyl-
Previous Indexing: Malonates (1974)
Public MeSH Note: 91; was see under MALONATES 1975-90
History Note: 91(75); was see under MALONATES 1975-90
DeCS ID: 8951
Unique ID: D008764
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/11
Revision Date: 2013/07/08
Methylmalonic Acid - Preferred
Concept UI M0013646
Scope note A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
Preferred term Methylmalonic Acid
Entry term(s) Acid, Methylmalonic



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