| Descriptor English: | Methylmalonyl-CoA Mutase | ||||||
| Descriptor Spanish: |
Metilmalonil-CoA Mutasa
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| Descriptor Portuguese: | Metilmalonil-CoA Mutase | ||||||
| Descriptor French: | Methylmalonyl-coA mutase | ||||||
| Entry term(s): |
Isomerase, Methylmalonyl-CoA Methylmalonyl CoA Isomerase Methylmalonyl CoA Mutase Methylmalonyl-CoA Isomerase Mutase, Methylmalonyl-CoA |
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| Tree number(s): |
D08.811.399.520.625 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D008765 | ||||||
| Scope note: | An enzyme that catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA by transfer of the carbonyl group. It requires a cobamide coenzyme. A block in this enzymatic conversion leads to the metabolic disease, methylmalonic aciduria. EC 5.4.99.2. |
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| Annotation: | /defic: consider also METHYLMALONIC ACID /urine (IM) + AMINO ACID METABOLISM, INBORN ERRORS (IM) |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 5.4.99.2 | ||||||
| CAS Type 1 Name: | (R)-2-Methyl-3-oxopropanoyl-CoA CoA-carbonylmutase | ||||||
| Previous Indexing: |
Isomerases (1969-1974) Malonates (1969-1974) |
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| Public MeSH Note: | 91; was see under ISOMERASES 1975-90 |
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| History Note: | 91(75); was see under ISOMERASES 1975-90 |
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| DeCS ID: | 8952 | ||||||
| Unique ID: | D008765 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1991/01/01 | ||||||
| Date of Entry: | 1974/11/11 | ||||||
| Revision Date: | 2003/07/09 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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Methylmalonyl-CoA Mutase
- Preferred
| Concept UI |
M0013647 |
| Scope note | An enzyme that catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA by transfer of the carbonyl group. It requires a cobamide coenzyme. A block in this enzymatic conversion leads to the metabolic disease, methylmalonic aciduria. EC 5.4.99.2. |
| Preferred term | Methylmalonyl-CoA Mutase |
| Entry term(s) |
Isomerase, Methylmalonyl-CoA Methylmalonyl CoA Isomerase Methylmalonyl CoA Mutase Methylmalonyl-CoA Isomerase Mutase, Methylmalonyl-CoA |
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