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Descriptor English: Nitric Oxide
Descriptor Spanish: Óxido Nítrico
Descriptor óxido nítrico
Scope note: Radical libre gaseoso producido endógenamente por distintas células de mamíferos. Es sintetizado a partir de la ARGININA por la ÓXIDO NÍTRICO SINTASA. El óxido nítrico es uno de los FACTORES RELAJANTES DERIVADOS DEL ENDOTELIO, liberados por el endotelio vascular y media la VASODILATACIÓN. También inhibe la agregación plaquetaria, induce la desagregación de las plaquetas agregadas e inhibe la adhesión de las plaquetas al endotelio vascular. El óxido nítrico activa la GUANILATO CICLASA citosólica, elevando así las concentraciones intracelulares de GMP CÍCLICO.
Descriptor Portuguese: Óxido Nítrico
Descriptor French: Monoxyde d'azote
Entry term(s): Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
Mononitrogen Monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
Nitric Oxide, Endothelium-Derived
Nitrogen Monoxide
Oxide, Nitric
Vasodilator, Endogenous Nitrate
Tree number(s): D01.339.387
D01.625.550.500
D01.625.700.500
D01.650.550.587.600
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009569
Scope note: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Bronchodilator Agents
Free Radical Scavengers
Neurotransmitter Agents
Endothelium-Dependent Relaxing Factors
Gasotransmitters
Registry Number: 31C4KY9ESH
CAS Type 1 Name: Nitrogen oxide (NO)
Public MeSH Note: 1965
History Note: 1965
Related: Endothelium-Dependent Relaxing Factors MeSH
Nitric Oxide Donors MeSH
DeCS ID: 9753
Unique ID: D009569
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08
Nitric Oxide - Preferred
Concept UI M0014877
Scope note A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Preferred term Nitric Oxide
Entry term(s) Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
Mononitrogen Monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
Nitric Oxide, Endothelium-Derived
Nitrogen Monoxide
Oxide, Nitric
Vasodilator, Endogenous Nitrate



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