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Descritor em português: | Enzimas de Restrição do DNA | ||||||
Descritor em inglês: | DNA Restriction Enzymes | ||||||
Descritor em espanhol: |
Enzimas de Restricción del ADN
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Descritor em francês: | DNA restriction enzymes | ||||||
Termo(s) alternativo(s): |
DNA Restriction Enzyme Endonuclease, Restriction Endonucleases, Restriction Enzymes, DNA Restriction Restriction Endonuclease Restriction Endonucleases Restriction Enzyme, DNA Restriction Enzymes, DNA |
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Código(s) hierárquico(s): |
D08.811.150.280 D08.811.277.352.335.350.300 D08.811.277.352.355.325.300 |
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Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D004262 | ||||||
Nota de escopo: | Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1. |
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Nota de indexação: | DNA restriction enzyme used as a DNA marker: coord probably NIM with GENETIC MARKER (IM) |
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Qualificadores permitidos: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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Número de registro: | EC 3.1.21.- | ||||||
Indexação Anterior: |
Deoxyribonucleases (1974) Endonucleases (1974) |
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Nota MeSH pública: | 79; was DNA RESTRICTION ENZYME 1978, was DNA RESTRICTION ENZYME see under ENDONUCLEASES 1975-77 |
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Nota Online: | use DNA RESTRICTION ENZYMES to search DNA RESTRICTION ENZYME l975-89 |
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Nota histórica: | 79; was DNA RESTRICTION ENZYME 1978, was DNA RESTRICTION ENZYME see under ENDONUCLEASES 1975-77 |
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Veja também os descritores: |
Polymorphism, Restriction Fragment Length
MeSH Restriction Mapping MeSH | ||||||
Identificador DeCS: | 23985 | ||||||
ID do descritor: | D004262 | ||||||
Classificação da NLM: | QU 136 | ||||||
Documentos indexados na Biblioteca Virtual em Saúde (BVS): | Clique aqui para acessar os documentos da BVS | ||||||
Data de estabelecimento: | 01/01/1978 | ||||||
Data de entrada: | 19/11/1974 | ||||||
Data de revisão: | 05/07/2006 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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DNA Restriction Enzymes
- Conceito preferido
Identificador do conceito |
M0006671 |
Nota de escopo | Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1. |
Termo preferido | DNA Restriction Enzymes |
Termo(s) alternativo(s) |
DNA Restriction Enzyme Endonuclease, Restriction Endonucleases, Restriction Enzymes, DNA Restriction Restriction Endonuclease Restriction Endonucleases Restriction Enzyme, DNA Restriction Enzymes, DNA |
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