| Descriptor in English: | Oncogenes |
| Descriptor in Spanish: | Oncogenes |
| Descriptor in Portuguese: | Oncogenes |
| Descriptor in French: | Oncogènes |
| Entry term(s): |
Gene, Transforming Genes, Transforming Oncogene Transforming Gene Transforming Genes |
| Tree number(s): |
G05.360.340.024.340.375.500 |
| Scope note: | Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene. |
| Annotation: | "oncogene" used by author may refer to ONCOGENES or PROTO-ONCOGENES; do not confuse with ONCOGENS see CARCINOGENS; Manual 24.4.4.3; do not confuse with GENES, NEOPLASM |
| Allowable Qualifiers: |
DE drug effects ES ethics GE genetics IM immunology PH physiology RE radiation effects |
| History Note: | 83 |
| DeCS UI: | 10040 |
| Descriptor UI: | D009857 |
| Date Established: | 1983/01/01 |
| Date of Entry: | 1982/04/22 |
| Revision Date: | 2008/07/08 |
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PHENOMENA AND PROCESSES
Genetic Phenomena [G05]Genetic Phenomena
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Oncogenes
- Preferred
| Concept UI |
M0015298 |
| Scope note | Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene. |
| Preferred term | Oncogenes |
| Entry term(s) |
Gene, Transforming Genes, Transforming Oncogene Transforming Gene Transforming Genes |
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