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Descriptor English: Oncogenes
Descriptor Spanish: Oncogenes
Descriptor oncogenes
Entry term(s) genes transformantes
Scope note: Genes cuya ganancia de función da lugar a TRANSFORMACIÓN NEOPLÁSICA CELULAR. Comprenden, por ejemplo, los genes de activadores o estimuladores de la PROLIFERACIÓN CELULAR, como factores de crecimiento, receptores de factores de crecimiento, proteína cinasas, transductores de señales, fosfoproteínas nucleares y factores de transcripción. El prefijo "v-" antes del símbolo de un oncogén indica que se trata de oncogenes capturados y transmitidos por RETROVIRUS; el prefijo "c-" antes del símbolo de un oncogén indica que se trata del homólogo celular (PROTO-ONCOGENES) de un v-oncogén.
Descriptor Portuguese: Oncogenes
Descriptor French: Oncogènes
Entry term(s): Gene, Transforming
Genes, Transforming
Oncogene
Transforming Gene
Transforming Genes
Tree number(s): G05.360.340.024.340.375.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009857
Scope note: Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.
Annotation: "oncogene" used by author may refer to ONCOGENES or PROTO-ONCOGENES; do not confuse with ONCOGENS see CARCINOGENS; Manual 24.4.4.3; do not confuse with GENES, NEOPLASM
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Genes (1966-1977)
Genes, Viral (1978-1982)
Public MeSH Note: 83
History Note: 83
DeCS ID: 10040
Unique ID: D009857
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1983/01/01
Date of Entry: 1982/04/22
Revision Date: 2008/07/08
Oncogenes - Preferred
Concept UI M0015298
Scope note Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.
Preferred term Oncogenes
Entry term(s) Gene, Transforming
Genes, Transforming
Oncogene
Transforming Gene
Transforming Genes



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