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Descriptor English: Physostigmine
Descriptor Spanish: Fisostigmina
Descriptor fisostigmina
Scope note: Inhibidor de la colinesterasa que se absorbe rápidamente a través de las membranas. Puede aplicarse tópicamante a la conjuntiva. Cruza también la barrera hematoencefálica y es utilizado cuando se desean efectos en el sistema nervioso central, como en el tratamiento de la toxicidad anticolinérgica grave.
Descriptor Portuguese: Fisostigmina
Descriptor French: Physostigmine
Entry term(s): Eserine
Tree number(s): D02.241.081.251.583.682
D03.132.436.545
D03.633.100.473.402.545
D03.633.100.496.500.500.545
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010830
Scope note: A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Cholinesterase Inhibitors
Miotics
Registry Number: 9U1VM840SP
CAS Type 1 Name: Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-
DeCS ID: 11262
Unique ID: D010830
NLM Classification: QV 124
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31
Physostigmine - Preferred
Concept UI M0016815
Scope note A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.
Preferred term Physostigmine
Eserine - Narrower
Concept UI M0351495
Preferred term Eserine



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