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Descriptor English: Quinacrine
Descriptor Spanish: Quinacrina
Descriptor quinacrina
Entry term(s) mepacrina
Scope note: Derivado de la acridina que, en el pasado, se utilizó ampliamente como antimalárico pero que actualmente ha sido reemplazado por la cloroquina. Se ha usado como antihelmíntico y en el tratamiento de la giardiasis y efusiones malignas. Se utiliza en experimentación biológica celular como un inhibidor de la fosfolipasa A2.
Descriptor Portuguese: Quinacrina
Descriptor French: Mépacrine
Entry term(s): Acrichine
Atabrine
Atebrin
Dihydrochloride, Quinacrine
Dimesylate, Quinacrine
Hydrochloride, Quinacrine
Mepacrine
Monoacetate, Quinacrine
Monohydrochloride, Quinacrine
Monomesylate, Quinacrine
Quinacrine Dihydrochloride
Quinacrine Dihydrochloride, Dihydrate
Quinacrine Dihyrochloride, (R)-Isomer
Quinacrine Dihyrochloride, (S)-Isomer
Quinacrine Dimesylate
Quinacrine Hydrochloride
Quinacrine Monoacetate
Quinacrine Monohydrochloride
Quinacrine Monomesylate
Quinacrine, (+-)-Isomer
Quinacrine, (R)-Isomer
Quinacrine, (S)-Isomer
Tree number(s): D03.633.300.046.250.760
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011796
Scope note: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anticestodal Agents
Antimalarials
Antinematodal Agents
Antineoplastic Agents
Enzyme Inhibitors
Registry Number: H0C805XYDE
CAS Type 1 Name: 1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-
Public MeSH Note: CHINACRIN was see QUINACRINE 1977-93
Online Note: use QUINACRINE to search CHINACRIN 1977-93
History Note: CHINACRIN was see QUINACRINE 1977-93
DeCS ID: 12233
Unique ID: D011796
NLM Classification: QV 258
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1960/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31
Quinacrine - Preferred
Concept UI M0018330
Scope note An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
Preferred term Quinacrine
Entry term(s) Atebrin
Mepacrine
Quinacrine, (S)-Isomer - Narrower
Concept UI M0329802
Preferred term Quinacrine, (S)-Isomer
Quinacrine Dihydrochloride - Narrower
Concept UI M0329675
Preferred term Quinacrine Dihydrochloride
Entry term(s) Dihydrochloride, Quinacrine
Quinacrine Dihydrochloride, Dihydrate - Narrower
Concept UI M0329673
Preferred term Quinacrine Dihydrochloride, Dihydrate
Quinacrine Dihyrochloride, (R)-Isomer - Narrower
Concept UI M0329672
Preferred term Quinacrine Dihyrochloride, (R)-Isomer
Quinacrine Dihyrochloride, (S)-Isomer - Narrower
Concept UI M0329671
Preferred term Quinacrine Dihyrochloride, (S)-Isomer
Atabrine - Narrower
Concept UI M0018333
Preferred term Atabrine
Quinacrine Monoacetate - Narrower
Concept UI M0329676
Preferred term Quinacrine Monoacetate
Entry term(s) Monoacetate, Quinacrine
Quinacrine Monohydrochloride - Narrower
Concept UI M0018332
Preferred term Quinacrine Monohydrochloride
Entry term(s) Hydrochloride, Quinacrine
Monohydrochloride, Quinacrine
Quinacrine Hydrochloride
Quinacrine Monomesylate - Narrower
Concept UI M0329801
Preferred term Quinacrine Monomesylate
Entry term(s) Monomesylate, Quinacrine
Quinacrine, (+-)-Isomer - Narrower
Concept UI M0329674
Preferred term Quinacrine, (+-)-Isomer
Acrichine - Narrower
Concept UI M0018331
Preferred term Acrichine
Quinacrine, (R)-Isomer - Narrower
Concept UI M0329739
Preferred term Quinacrine, (R)-Isomer
Quinacrine Dimesylate - Narrower
Concept UI M0329670
Preferred term Quinacrine Dimesylate
Entry term(s) Dimesylate, Quinacrine



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