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Descriptor in English: Rifampin
Descriptor in Spanish: Rifampin
Descriptor in Portuguese: Rifampina
Descriptor in French: Rifampicine
Entry term(s): Benemycin
Rifadin
Rifampicin
Rimactan
Rimactane
Tubocin
Tree number(s): D03.633.400.811.700
D04.345.295.750.700
Scope note: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 73
DeCS UI: 12705
Descriptor UI: D012293
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31
Rifampin - Preferred
Concept UI M0019110
Scope note A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Preferred term Rifampin
Entry term(s) Benemycin
Rifampicin
Rimactan - Narrower
Concept UI M0373213
Preferred term Rimactan
Tubocin - Narrower
Concept UI M0373212
Preferred term Tubocin
Rifadin - Narrower
Concept UI M0019111
Preferred term Rifadin
Rimactane - Narrower
Concept UI M0019112
Preferred term Rimactane



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