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Descriptor English: Rifampin
Descriptor Spanish: Rifampin
Descriptor rifampicina
Entry term(s) rifampin
Scope note: Antibiótico semisintético producido a partir de Streptomyces mediterranei. Tiene un amplio espectro antibacteriano, incluida la actividad contra varias formas de Mycobacterium. En organismos sensibles a este fármaco, inhibe la actividad de la ARN polimerasa dependiente del ADN formando un complejo estable con la enzima. De este modo, suprime la iniciación de la síntesis de ARN. La rifampicina es bactericida, y actúa tanto en microorganismos intracelulares como extracelulares.
Descriptor Portuguese: Rifampicina
Descriptor French: Rifampicine
Entry term(s): Benemycin
Rifadin
Rifampicin
Rimactan
Rimactane
Tubocin
Tree number(s): D03.633.400.811.700
D04.345.295.750.700
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D012293
Scope note: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antibiotics, Antitubercular
Leprostatic Agents
Nucleic Acid Synthesis Inhibitors
Cytochrome P-450 CYP2B6 Inducers
Cytochrome P-450 CYP2C8 Inducers
Cytochrome P-450 CYP2C19 Inducers
Cytochrome P-450 CYP2C9 Inducers
Cytochrome P-450 CYP3A Inducers
Registry Number: VJT6J7R4TR
CAS Type 1 Name: Rifamycin, 3-(((4-methyl-1-piperazinyl)imino)methyl)-
Previous Indexing: Rifamycins (1966-1972)
Public MeSH Note: 73
History Note: 73
DeCS ID: 12705
Unique ID: D012293
NLM Classification: QV 268
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31
Rifampin - Preferred
Concept UI M0019110
Scope note A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Preferred term Rifampin
Entry term(s) Benemycin
Rifampicin
Rimactan - Narrower
Concept UI M0373213
Preferred term Rimactan
Tubocin - Narrower
Concept UI M0373212
Preferred term Tubocin
Rifadin - Narrower
Concept UI M0019111
Preferred term Rifadin
Rimactane - Narrower
Concept UI M0019112
Preferred term Rimactane



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