| Descriptor in English: | Rifampin |
| Descriptor in Spanish: | Rifampin |
| Descriptor in Portuguese: | Rifampina |
| Descriptor in French: | Rifampicine |
| Entry term(s): |
Benemycin Rifadin Rifampicin Rimactan Rimactane Tubocin |
| Tree number(s): |
D03.633.400.811.700 D04.345.295.750.700 |
| Scope note: | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160) |
| Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
| History Note: | 73 |
| DeCS UI: | 12705 |
| Descriptor UI: | D012293 |
| Date Established: | 1973/01/01 |
| Date of Entry: | 1999/01/01 |
| Revision Date: | 2016/05/31 |
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CHEMICALS AND DRUGS
Heterocyclic Compounds [D03]Heterocyclic Compounds -
CHEMICALS AND DRUGS
Polycyclic Compounds [D04]Polycyclic Compounds
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Rifampin
- Preferred
Rimactan
- Narrower
Tubocin
- Narrower
Rifadin
- Narrower
Rimactane
- Narrower
| Concept UI |
M0019110 |
| Scope note | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160) |
| Preferred term | Rifampin |
| Entry term(s) |
Benemycin Rifampicin |
| Concept UI |
M0373213 |
| Preferred term | Rimactan |
| Concept UI |
M0373212 |
| Preferred term | Tubocin |
| Concept UI |
M0019111 |
| Preferred term | Rifadin |
| Concept UI |
M0019112 |
| Preferred term | Rimactane |
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