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Descriptor English: Sphingomyelin Phosphodiesterase
Descriptor Spanish: Esfingomielina Fosfodiesterasa
Descriptor esfingomielina fosfodiesterasa
Entry term(s) enzima de escisión de la esfingomielina
esfingomielina colinafosfohidrolasa
esfingomielinasa
Scope note: Enzima que cataliza la hidrólisis de esfingomielina formando ceramida (N-acilesfingosina) más fosfato de colina. Un defecto de esta enzima produce la ENFERMEDAD DE NIEMANN-PICK. EC 3.1.4.12.
Descriptor Portuguese: Esfingomielina Fosfodiesterase
Descriptor French: Sphingomyeline phosphodiesterase
Entry term(s): Sphingomyelin Cholinephosphohydrolase
Sphingomyelin Cleaving Enzyme
Sphingomyelinase
Sphingomyelinase C
Tree number(s): D08.811.277.352.640.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013108
Scope note: An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.
Annotation: /defic: consider also NIEMANN-PICK DISEASE
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.4.12
CAS Type 1 Name: Sphingomyelin cholinephosphohydrolase
Previous Indexing: Phosphodiesterases (1973-1974)
Sphingomyelins (1973-1974)
Public MeSH Note: 91; was see under PHOSPHODIESTERASES 1975-90
History Note: 91(75); was see under PHOSPHODIESTERASES 1975-90
Related: Niemann-Pick Diseases MeSH
DeCS ID: 13491
Unique ID: D013108
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2003/07/09
Sphingomyelin Phosphodiesterase - Preferred
Concept UI M0020300
Scope note An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.
Preferred term Sphingomyelin Phosphodiesterase
Entry term(s) Sphingomyelin Cholinephosphohydrolase
Sphingomyelin Cleaving Enzyme
Sphingomyelinase
Sphingomyelinase C



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