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Descriptor English: Phosphodiesterase I
Descriptor Spanish: Fosfodiesterasa I
Descriptor fosfodiesterasa I
Scope note: Diéster fosfórico hidrolasa que elimina 5'-nucleótidos desde los extremos 3'-hidroxi de los OLIGONUCLEÓTIDOS con extremos 3'-hidroxi. Tiene escasa actividad respecto a los OLIGONUCLEÓTIDOS y la presencia de 3'-fosfato terminal en el sustrato puede inhibir la hidrólisis.
Descriptor Portuguese: Fosfodiesterase I
Descriptor French: Phosphodiesterase I
Entry term(s): 5' Exonuclease
5' Nucleotidephosphodiesterase
5'-Exonuclease
5'-Nucleotidephosphodiesterase
Alkaline Phosphodiesterase
Alkaline Phosphodiesterase I
Diester Phosphohydrolase, Orthophosphoric
Oligonucleate 5' Nucleotidohydrolase
Oligonucleate 5'-Nucleotidohydrolase
Orthophosphoric Diester Phosphohydrolase
Phosphodiesterase I, Alkaline
Phosphodiesterase, Alkaline
Phosphohydrolase, Orthophosphoric Diester
Tree number(s): D08.811.277.352.640.430
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D043264
Scope note: A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.4.1
Previous Indexing: Phosphoric Diester Hydrolases (1978-2003)
Public MeSH Note: 2004; PHOSPHODIESTERASE I was indexed under PHOSPHORIC DIESTER HYDROLASES 1981-2003, under NUCLEOTIDES 1978-1980
History Note: 2004; use PHOSPHODIESTERASE I (NM) 1980-2003
DeCS ID: 38147
Unique ID: D043264
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Phosphodiesterase I - Preferred
Concept UI M0078260
Scope note A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis.
Preferred term Phosphodiesterase I
Entry term(s) 5' Exonuclease
5' Nucleotidephosphodiesterase
5'-Exonuclease
5'-Nucleotidephosphodiesterase
Alkaline Phosphodiesterase
Alkaline Phosphodiesterase I
Diester Phosphohydrolase, Orthophosphoric
Oligonucleate 5' Nucleotidohydrolase
Oligonucleate 5'-Nucleotidohydrolase
Orthophosphoric Diester Phosphohydrolase
Phosphodiesterase I, Alkaline
Phosphodiesterase, Alkaline
Phosphohydrolase, Orthophosphoric Diester



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