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Descriptor in English: Tamoxifen
Descriptor in Spanish: Tamoxifeno
Descriptor in Portuguese: Tamoxifeno
Descriptor in French: Tamoxifène
Entry term(s): Citrate, Tamoxifen
ICI 46,474
ICI 46474
ICI 47699
ICI-46,474
ICI-46474
ICI-47699
ICI46,474
ICI46474
ICI47699
Nolvadex
Novaldex
Soltamox
Tamoxifen Citrate
Tomaxithen
Zitazonium
Tree number(s): D02.455.426.559.389.150.700.900
Scope note: One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 78(75); was see under STILBENES 1975-77
DeCS UI: 14010
Descriptor UI: D013629
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2016/07/01
Tamoxifen - Preferred
Concept UI M0021024
Scope note One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.
Preferred term Tamoxifen
ICI-47699 - Narrower
Concept UI M0021027
Preferred term ICI-47699
Entry term(s) ICI 47699
ICI47699
Nolvadex - Narrower
Concept UI M0373247
Preferred term Nolvadex
Entry term(s) Novaldex
Tamoxifen Citrate - Narrower
Concept UI M0373246
Preferred term Tamoxifen Citrate
Entry term(s) Citrate, Tamoxifen
Tomaxithen - Narrower
Concept UI M0021028
Preferred term Tomaxithen
Zitazonium - Narrower
Concept UI M0021025
Preferred term Zitazonium
ICI-46474 - Narrower
Concept UI M0021026
Preferred term ICI-46474
Entry term(s) ICI 46,474
ICI 46474
ICI-46,474
ICI46,474
ICI46474
Soltamox - Narrower
Concept UI M0495698
Preferred term Soltamox



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