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Descriptor English: | Thalidomide | ||||
Descriptor Spanish: |
Talidomida
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Descriptor Portuguese: | Talidomida | ||||
Descriptor French: | Thalidomide | ||||
Tree number(s): |
D02.241.223.805.810.800 D03.383.621.808.800 D03.633.100.513.750.750 |
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RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D013792 | ||||
Scope note: | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action. |
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Allowable Qualifiers: |
AA analogues et dérivés AD administration et posologie AE effets indésirables AG agonistes AI antagonistes et inhibiteurs AN analyse BL sang CF liquide cérébrospinal CH composition chimique CL classification CS synthèse chimique EC économie HI histoire IM immunologie IP isolement et purification ME métabolisme PD pharmacologie PK pharmacocinétique PO intoxication RE effets des radiations SD ressources et distribution ST normes TO toxicité TU usage thérapeutique UR urine |
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Pharm Action: |
Immunosuppressive Agents Leprostatic Agents Teratogens Angiogenesis Inhibitors |
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Registry Number: | 4Z8R6ORS6L | ||||
CAS Type 1 Name: | 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)- | ||||
DeCS ID: | 14171 | ||||
Unique ID: | D013792 | ||||
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||
Date Established: | 1966/01/01 | ||||
Date of Entry: | 1999/01/01 | ||||
Revision Date: | 2017/05/24 |
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PRODUITS CHIMIQUES ET PHARMACEUTIQUES
Composés chimiques organiques [D02]Composés chimiques organiques -
PRODUITS CHIMIQUES ET PHARMACEUTIQUES
Composés hétérocycliques [D03]Composés hétérocycliques -
PRODUITS CHIMIQUES ET PHARMACEUTIQUES
Composés hétérocycliques [D03]Composés hétérocycliques
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