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Descriptor English: Tryptophanase
Descriptor Spanish: Triptofanasa
Descriptor triptofanasa
Entry term(s) triptófano indol liasa
Scope note: Enzima que cataliza la conversión de L-triptofano y agua en indol, piruvato y amoníaco. Es una proteína con fosfato de piridoxal que requiere K+. También cataliza las reacciones de 2,3-eliminación y beta-sustitución de algunos análogos del triptofano sustituído en el indol de L-cisteína, L-serina y otros aminoácidos sustituídos en la posición 3. (Enzyme Nomenclature, 1992) EC 4.1.99.1.
Descriptor Portuguese: Triptofanase
Descriptor French: Tryptophanase
Entry term(s): Indole-Lyase, Tryptophan
Tryptophan Indole Lyase
Tryptophan Indole-Lyase
Tree number(s): D08.811.520.224.800
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D014368
Scope note: An enzyme that catalyzes the conversion of L-tryptophan and water to indole, pyruvate, and ammonia. It is a pyridoxal-phosphate protein, requiring K+. It also catalyzes 2,3-elimination and beta-replacement reactions of some indole-substituted tryptophan analogs of L-cysteine, L-serine, and other 3-substituted amino acids. (From Enzyme Nomenclature, 1992) EC 4.1.99.1.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 4.1.99.1
CAS Type 1 Name: L-Tryptophan indole-lyase (deaminating)
Previous Indexing: Hydro-Lyases (1966-1971)
Public MeSH Note: 91; was see under LYASES 1972-90
History Note: 91(72); was see under LYASES 1972-90
DeCS ID: 14770
Unique ID: D014368
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1999/01/01
Revision Date: 2003/07/09
Tryptophanase - Preferred
Concept UI M0022093
Scope note An enzyme that catalyzes the conversion of L-tryptophan and water to indole, pyruvate, and ammonia. It is a pyridoxal-phosphate protein, requiring K+. It also catalyzes 2,3-elimination and beta-replacement reactions of some indole-substituted tryptophan analogs of L-cysteine, L-serine, and other 3-substituted amino acids. (From Enzyme Nomenclature, 1992) EC 4.1.99.1.
Preferred term Tryptophanase
Entry term(s) Indole-Lyase, Tryptophan
Tryptophan Indole Lyase
Tryptophan Indole-Lyase



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