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Descriptor English: Vinca Alkaloids
Descriptor Spanish: Alcaloides de la Vinca
Descriptor alcaloides de la vinca
Scope note: Grupo de dimeros del indol-indolin que son ALCALOIDES obtenidos de la VINCA. Inhiben la polimerización de la TUBULINA en los MICROTÚBULOS, bloqueando y deteniendo la formación de células del raquis en la METAFASE. Son uno de los más útiles AGENTES ANTINEOPLÁSICOS. Una clase de alcaloides del género de hierbas apocianáceas incluyendo la vincapervinca. Son algunos de los agentes antineoplásicos más útiles.
Descriptor Portuguese: Alcaloides de Vinca
Descriptor French: Alcaloïdes de Vinca
Entry term(s): Alkaloids, Vinca
Tree number(s): D03.132.436.681.827
D03.633.100.473.402.681.827
D03.633.100.496.500.500.681.827
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D014748
Scope note: A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents
Tubulin Modulators
Previous Indexing: Alkaloids (1966-1972)
Public MeSH Note: 73
History Note: 73
DeCS ID: 15153
Unique ID: D014748
NLM Classification: QV 269
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/01
Vinca Alkaloids - Preferred
Concept UI M0022674
Scope note A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS.
Preferred term Vinca Alkaloids
Entry term(s) Alkaloids, Vinca



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