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Descriptor English: Busulfan
Descriptor Spanish: Busulfano
Descriptor busulfán
Entry term(s) busulfano
Scope note: Agente alquilante que tiene un efecto inmunosupresor selectivo sobre la MÉDULA ÓSEA. Ha sido utilizado como tratamiento paliativo en la leucemia mieloide crónica (LEUCEMIA MIELOIDE CRÓNICA), pero aunque logra alivio sintomático, no se alcanza la remisión completa. Según el Fourth Annual Report on Carcinogens (NTP 85-002, 1985), el busulfán está en la lista de carcinógenos conocidos.
Descriptor Portuguese: Bussulfano
Descriptor French: Busulfan
Entry term(s): Busulfan Wellcome
Busulfex
Busulphan
Glyzophrol
Myelosan
Mylecytan
Myleran
Myléran
Wellcome, Busulfan
n-Butane-1,3-di(methylsulfonate)
Tree number(s): D02.033.455.125.125
D02.455.326.146.100.050.500.100
D02.886.645.600.055.050.510.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002066
Scope note: An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Alkylating Agents
Immunosuppressive Agents
Antineoplastic Agents, Alkylating
Myeloablative Agonists
Registry Number: G1LN9045DK
CAS Type 1 Name: 1,4-Butanediol, dimethanesulfonate
DeCS ID: 2098
Unique ID: D002066
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/05
Busulfan - Preferred
Concept UI M0003079
Scope note An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Preferred term Busulfan
Entry term(s) Busulphan
Busulfan Wellcome - Narrower
Concept UI M0466352
Preferred term Busulfan Wellcome
Entry term(s) Wellcome, Busulfan
Busulfex - Narrower
Concept UI M0466353
Preferred term Busulfex
Myleran - Narrower
Concept UI M0003081
Preferred term Myleran
Entry term(s) Myléran
Myelosan - Narrower
Concept UI M0350678
Preferred term Myelosan
Mylecytan - Narrower
Concept UI M0350677
Preferred term Mylecytan
n-Butane-1,3-di(methylsulfonate) - Related but not broader or narrower
Concept UI M0003080
Preferred term n-Butane-1,3-di(methylsulfonate)
Glyzophrol - Narrower
Concept UI M0350679
Preferred term Glyzophrol



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