Search
Descriptor English: C-Peptide
Descriptor Spanish: Péptido C
Descriptor péptido C
Entry term(s) péptido C de la proinsulina
péptido-C
péptido-C de la proinsulina
Scope note: Segmento medio de la proinsulina que se encuentra entre la cadena B N-terminal y la cadena A C-terminal. Es un péptido pancreático con unos 31 residuos, dependiendo de las especies. Después de la escisión proteolítica de la proinsulina, se liberan en cantidades equimolares INSULINA y péptido C. Se ha usado el inmunoensayo para determinar el péptido C a fin de evaluar la función de las células beta pancreáticas en pacientes diabéticos con anticuerpos antiinsulínicos circulantes o que reciben insulina exógena. La semivida del péptido C es de 30 minutos, unas 8 veces superior a la de la insulina.
Descriptor Portuguese: Peptídeo C
Descriptor French: Peptide C
Entry term(s): C Peptide
C Peptide, Proinsulin
C-Peptide, Proinsulin
Connecting Peptide
Proinsulin C Peptide
Proinsulin C-Peptide
Tree number(s): D06.472.699.587.200.500.250
D12.644.548.586.200.500.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002096
Scope note: The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.
Annotation: from proinsulin only: not for peptide fragments from other proteins ( = PEPTIDE FRAGMENTS)
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Peptides (1973-1976)
Proinsulin (1975-1976)
Public MeSH Note: 84; was see under PEPTIDES 1977-83
History Note: 84(77); was see under PEPTIDES 1977-83
DeCS ID: 2130
Unique ID: D002096
NLM Classification: WK 820
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1984/01/01
Date of Entry: 1976/04/16
Revision Date: 2011/06/24
C-Peptide - Preferred
Concept UI M0003121
Scope note The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.
Preferred term C-Peptide
Entry term(s) C Peptide
C Peptide, Proinsulin
C-Peptide, Proinsulin
Connecting Peptide
Proinsulin C Peptide
Proinsulin C-Peptide



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.

Go to survey