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Descriptor English: Hemoglobin, Sickle
Descriptor Spanish: Hemoglobina Falciforme
Descriptor hemoglobina de la drepanocitosis
Entry term(s) hemoglobina S
Scope note: Hemoglobina anormal consecuencia de la sustitución de valina en lugar de ácido glutámico en la posición 6 de la cadena beta de la porción globina. El estado heterocigosidad da lugar al rasgo de la célula drepanocítica, mientras que el de homocigosidad a anemia de células falciformes.
Descriptor Portuguese: Hemoglobina Falciforme
Descriptor French: Hémoglobine S
Entry term(s): Deoxygenated Sickle Hemoglobin
Deoxyhemoglobin S
Hemoglobin S
Hemoglobin SS
Hemoglobin, Deoxygenated Sickle
SS, Hemoglobin
Sickle Hemoglobin
Sickle Hemoglobin, Deoxygenated
Tree number(s): D12.776.124.400.463.588
D12.776.422.316.762.426.588
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D006451
Scope note: An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
Annotation: /urine: coord IM with HEMOGLOBINURIA (IM); hemoglobin S disease = ANEMIA, SICKLE CELL
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Hemoglobins, Abnormal (1966-1972)
Public MeSH Note: 77
Online Note: use HEMOGLOBIN, SICKLE to search HEMOGLOBIN S 1973-74 (as Prov)
History Note: 77(75); was HEMOGLOBIN S 1973-74 (Prov)
Entry Version: HBS
DeCS ID: 22197
Unique ID: D006451
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1977/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/28
Hemoglobin, Sickle - Preferred
Concept UI M0010127
Scope note An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
Preferred term Hemoglobin, Sickle
Entry term(s) Hemoglobin S
Sickle Hemoglobin
Deoxyhemoglobin S - Narrower
Concept UI M0010125
Preferred term Deoxyhemoglobin S
Entry term(s) Deoxygenated Sickle Hemoglobin
Hemoglobin, Deoxygenated Sickle
Sickle Hemoglobin, Deoxygenated
Hemoglobin SS - Narrower
Concept UI M0010126
Preferred term Hemoglobin SS
Entry term(s) SS, Hemoglobin



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