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Descriptor English: Pyroglobulins
Descriptor Spanish: Piroglobulinas
Descriptor piroglobulinas
Scope note: Inmunoglobulinas gamma atípicas caracterizadas por desnaturalización por calor irreversible a 56 grados centígrados. La piroprecipitación se inhibe a un pH menor de 3 y mayor de 9. La presencia de piroglobulinas en el suero es la causa de la piroglobulinemia. Se hallan presentes con frecuencia en el mieloma múltiple y el precipitado de piroglobulinas se une al complemento, reacciona con el factor reumatoide, produce anafilaxia cutánea pasiva, anafilaxia pasiva generalizada y fenómeno pasivo de tipo Arthus.
Descriptor Portuguese: Piroglobulinas
Descriptor French: Pyroglobulines
Tree number(s): D12.776.124.486.485.900.700
D12.776.124.790.651.900.700
D12.776.377.715.548.900.700
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011750
Scope note: Atypical gamma immunoglobulins characterized by their irreversible heat denaturation at 56-degrees C. Pyroprecipitation is inhibited at pH below 3 and above 9. The presence of pyroglobulins in the serum is the cause of pyroglobulinemia. They are frequently present in multiple myeloma and the pyroglobulin precipitate binds complement, reacts with rheumatoid factor, produces passive cutaneous anaphylaxis, generalized passive anaphylaxis and passive Arthus-type phenomena.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Previous Indexing: Heat (1972-1975)
Immunoglobulins (1972-1975)
Precipitation (1972-1975)
Public MeSH Note: 91; was see under PARAPROTEINS 1976-90
History Note: 91(76); was see under PARAPROTEINS 1976-90
DeCS ID: 22273
Unique ID: D011750
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1975/08/01
Revision Date: 2005/06/30
Pyroglobulins - Preferred
Concept UI M0018269
Scope note Atypical gamma immunoglobulins characterized by their irreversible heat denaturation at 56-degrees C. Pyroprecipitation is inhibited at pH below 3 and above 9. The presence of pyroglobulins in the serum is the cause of pyroglobulinemia. They are frequently present in multiple myeloma and the pyroglobulin precipitate binds complement, reacts with rheumatoid factor, produces passive cutaneous anaphylaxis, generalized passive anaphylaxis and passive Arthus-type phenomena.
Preferred term Pyroglobulins



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