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Descriptor English: Complement C3b
Descriptor Spanish: Complemento C3b
Descriptor complemento C3b
Scope note: El mayor fragmento generado de la escisión del COMPLEMENTO C3 por la C3 CONVERTASA. Es un constituyente de la C3 CONVERTASA DE LA VÍA ALTERNATIVA (C3bBb), y de las CONVERTASAS del COMPLEMENTO C3 tanto en la vía clásica (C4b2a3b) como alternativa (C3bB3b). C3b participa en la REACCIÓN DE INMUNOADHERENCIA y favorece la FAGOCITOSIS. Puede ser inactivada (iC3b) o desdoblada por varias proteasas produciéndose fragmentos tales como el COMPLEMENTO C3C, COMPLEMENTO C3B, C3e, C3f y C3g.
Descriptor Portuguese: Complemento C3b
Descriptor French: Complément C3b
Entry term(s): C3b Complement
C3b, Complement
C3b, Inactivated
C3bi
Complement 3b
Complement Component 3b
Complement, C3b
Component 3b, Complement
Inactivated C3b
iC3b
Tree number(s): D12.776.124.486.274.250.260
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003179
Scope note: The larger fragment generated from the cleavage of COMPLEMENT C3 by C3 CONVERTASE. It is a constituent of the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb), and COMPLEMENT C5 CONVERTASES in both the classical (C4b2a3b) and the alternative (C3bBb3b) pathway. C3b participates in IMMUNE ADHERENCE REACTION and enhances PHAGOCYTOSIS. It can be inactivated (iC3b) or cleaved by various proteases to yield fragments such as COMPLEMENT C3C; COMPLEMENT C3D; C3e; C3f; and C3g.
Annotation: /antag: consider COMPLEMENT C3B INACTIVATOR PROTEINS
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Registry Number: 80295-43-8
CAS Type 1 Name: Complement C3b
Previous Indexing: Complement (1968-1974)
Complement 3 (1975-1977)
Public MeSH Note: 2006; see COMPLEMENT 3B 1978-2005
History Note: 2006 (1978)
Related: Receptors, Complement 3b MeSH
DeCS ID: 22315
Unique ID: D003179
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1978/01/01
Date of Entry: 1977/05/17
Revision Date: 2013/07/09
Complement C3b - Preferred
Concept UI M0004932
Scope note The larger fragment generated from the cleavage of COMPLEMENT C3 by C3 CONVERTASE. It is a constituent of the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb), and COMPLEMENT C5 CONVERTASES in both the classical (C4b2a3b) and the alternative (C3bBb3b) pathway. C3b participates in IMMUNE ADHERENCE REACTION and enhances PHAGOCYTOSIS. It can be inactivated (iC3b) or cleaved by various proteases to yield fragments such as COMPLEMENT C3C; COMPLEMENT C3D; C3e; C3f; and C3g.
Preferred term Complement C3b
Entry term(s) C3b Complement
C3b, Complement
Complement 3b
Complement Component 3b
Complement, C3b
Component 3b, Complement
Inactivated C3b - Narrower
Concept UI M0004931
Preferred term Inactivated C3b
Entry term(s) C3b, Inactivated
C3bi
iC3b



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