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Descriptor English: Complement C3a
Descriptor Spanish: Complemento C3a
Descriptor complemento C3a
Scope note: El fragmento más pequeño generado a partir del desdoblamiento del complemento C3 por la CONVERTASA C3. El C3a, péptido de 77 aminoácidos, es un mediador del proceso inflamatorio local. Induce la CONTRACCIÓN DEL MÚSCULO liso y la LIBERACIÓN DE HISTAMINA de las CÉLULAS CEBADAS y LEUCOCITOS. Se considera que C3a es una anafilatoxina junto con el COMPLEMENTO C4A, COMPLEMENTO C5A y COMPLEMENTO C5A DES-ARGININA.
Descriptor Portuguese: Complemento C3a
Descriptor French: Complément C3a
Entry term(s): C3a Complement
C3a, Complement
Complement 3a
Complement Component 3a
Complement, C3a
Component 3a, Complement
Tree number(s): D12.776.124.486.274.024.250
D12.776.124.486.274.250.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015926
Scope note: The smaller fragment generated from the cleavage of complement C3 by C3 CONVERTASE. C3a, a 77-amino acid peptide, is a mediator of local inflammatory process. It induces smooth MUSCLE CONTRACTION, and HISTAMINE RELEASE from MAST CELLS and LEUKOCYTES. C3a is considered an anaphylatoxin along with COMPLEMENT C4A; COMPLEMENT C5A; and COMPLEMENT C5A, DES-ARGININE.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Registry Number: 80295-42-7
CAS Type 1 Name: Complement C3a
Previous Indexing: Anaphylatoxins (1977-1989)
Complement (1967-1976)
Complement 3 (1975-1989)
Public MeSH Note: 2006; see COMPLEMENT 3A 1990-2005
History Note: 2006 (1990)
DeCS ID: 24575
Unique ID: D015926
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/07/14
Revision Date: 2013/07/09
Complement C3a - Preferred
Concept UI M0024371
Scope note The smaller fragment generated from the cleavage of complement C3 by C3 CONVERTASE. C3a, a 77-amino acid peptide, is a mediator of local inflammatory process. It induces smooth MUSCLE CONTRACTION, and HISTAMINE RELEASE from MAST CELLS and LEUKOCYTES. C3a is considered an anaphylatoxin along with COMPLEMENT C4A; COMPLEMENT C5A; and COMPLEMENT C5A, DES-ARGININE.
Preferred term Complement C3a
Entry term(s) C3a Complement
C3a, Complement
Complement 3a
Complement Component 3a
Complement, C3a
Component 3a, Complement



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