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Descriptor English: Receptors, LDL
Descriptor Spanish: Receptores de LDL
Descriptor receptores de LDL
Entry term(s) receptores de lipoproteínas LDL
receptores de lipoproteínas de baja densidad
Scope note: Receptores de la membrana plasmática de las células no hepáticas que se unen específicamente a las LDL. Estos receptores están localizados en regiones especializadas denominadas invaginaciones cubiertas. La hipercolesterolemia está causada por un defecto genético alélico de tres tipos: 1, receptores que no se unen a las LDL; 2, existe una disminución de unión al LDL; y 3, existe una unión normal sin internalización de las LDL. Consecuentemente, la entrada de ésteres de colesterol en la célula se ve impedida, con pérdida de la autorregulación intracelular por el colesterol de la 3-hidroxi-3-metilglutaril-CoA reductasa.
Descriptor Portuguese: Receptores de LDL
Descriptor French: Récepteurs aux lipoprotéines LDL
Entry term(s): LDL Receptor
LDL Receptors
LDL Receptors, Lipoprotein
Lipoprotein LDL Receptors
Low Density Lipoprotein Receptor
Low Density Lipoprotein Receptors
Receptor, LDL
Receptors, Lipoprotein LDL
Receptors, Lipoprotein, LDL
Receptors, Low Density Lipoprotein
Tree number(s): D12.776.543.750.710.450
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011973
Scope note: Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Previous Indexing: Lipoproteins, LDL (1972-1984)
Receptors, Endogenous Substances (1973-1984)
Public MeSH Note: 85; LIPOPROTEINS, LDL RECEPTORS was see RECEPTORS, LDL 1985-92
Online Note: use RECEPTORS, LDL to search LIPOPROTEINS, LDL RECEPTORS 1985-92
History Note: 85; LIPOPROTEINS, LDL RECEPTORS was see RECEPTORS, LDL 1985-92
Entry Version: RECEPT LDL
Related: Lipoproteins, LDL MeSH
DeCS ID: 22650
Unique ID: D011973
NLM Classification: QU 95
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1985/01/01
Date of Entry: 1984/05/25
Revision Date: 2006/07/05
Receptors, LDL - Preferred
Concept UI M0018606
Scope note Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.
Preferred term Receptors, LDL
Entry term(s) LDL Receptor
LDL Receptors
LDL Receptors, Lipoprotein
Lipoprotein LDL Receptors
Low Density Lipoprotein Receptor
Low Density Lipoprotein Receptors
Receptor, LDL
Receptors, Lipoprotein LDL
Receptors, Lipoprotein, LDL
Receptors, Low Density Lipoprotein



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