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Descriptor English: Calcium Channel Agonists
Descriptor Spanish: Agonistas de los Canales de Calcio
Descriptor agonistas de los canales del calcio
Entry term(s) activadores de los canales de calcio
agonistas de los canales de calcio exógenos
agonistas exógenos de los canales de calcio
Scope note: Sustancias que incrementan el flujo de entrada del calcio dentro de los canales del calcio de los tejidos excitables. Esto causa vasoconstricción en el MÚSCULO LISO VASCULAR y-o en las células del MÚSCULO CARDÍACO, así como estimulación de la liberación de insulina por los islotes pancreáticos. Por tanto, los agonistas del calcio selectivos de tejido, se pueden usar para el tratamiento de la insuficiencia cardíaca y de los trastornos endocrinológicos. Se han utilizado principalmente en estudios experimentales de cultivos celulares y tisulares.
Descriptor Portuguese: Agonistas dos Canais de Cálcio
Descriptor French: Agonistes des canaux calciques
Entry term(s): Activators, Calcium Channel
Agonist, Calcium Channel
Agonists, Calcium Channel
Calcium Channel Activators
Calcium Channel Agonist
Calcium Channel Agonists, Exogenous
Channel Activators, Calcium
Channel Agonist, Calcium
Channel Agonists, Calcium
Exogenous Calcium Channel Agonists
Tree number(s): D27.505.519.562.124
D27.505.696.260.250
D27.505.954.411.793.205
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002120
Scope note: Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.
Annotation: vasoconstrictors; DF: CALCIUM CHANNEL AGON or CALCIUM CHANNEL AG
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Entry Combination: antagonists & inhibitors:Calcium Channel Blockers
Previous Indexing: Calcium/metab (1966-1987)
Ion Channels (1979-1987)
Public MeSH Note: 88
History Note: 88
Entry Version: CALCIUM CHANNEL AG
DeCS ID: 22856
Unique ID: D002120
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1988/01/01
Date of Entry: 1987/03/23
Revision Date: 2018/05/22
Calcium Channel Agonists - Preferred
Concept UI M0003163
Scope note Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.
Preferred term Calcium Channel Agonists
Entry term(s) Activators, Calcium Channel
Agonist, Calcium Channel
Agonists, Calcium Channel
Calcium Channel Activators
Calcium Channel Agonist
Channel Activators, Calcium
Channel Agonist, Calcium
Channel Agonists, Calcium
Exogenous Calcium Channel Agonists - Narrower
Concept UI M0003164
Preferred term Exogenous Calcium Channel Agonists
Entry term(s) Calcium Channel Agonists, Exogenous



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