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Descriptor English: Addison Disease
Descriptor Spanish: Enfermedad de Addison
Descriptor enfermedad de Addison
Scope note: Enfermedad de las glándulas suprarrenales caracterizada por una destrucción progresiva de la CORTEZA SUPRARRENAL, que provoca una deficiente producción de ALDOSTERONA e HIDROCORTISONA. Los síntomas clínicos son: ANOREXIA, NÁUSEA, PÉRDIDA DE PESO, DEBILIDAD MUSCULAR e HIPERPIGMENTACIÓN de la PIEL, debida a un aumento de los niveles circulantes del precursor de la hormona ACTH, que estimula a los MELANOCITOS.
Descriptor Portuguese: Doença de Addison
Descriptor French: Maladie d'Addison
Entry term(s): Addison's Disease
Addisons Disease
Adrenal Insufficiency, Primary
Adrenocortical Insufficiencies, Primary
Adrenocortical Insufficiency, Primary
Disease, Addison
Hypoadrenalism, Primary
Hypoadrenalisms, Primary
Insufficiencies, Primary Adrenocortical
Insufficiency, Primary Adrenocortical
Primary Adrenal Insufficiency
Primary Adrenocortical Insufficiencies
Primary Adrenocortical Insufficiency
Primary Hypoadrenalism
Tree number(s): C19.053.500.263
C20.111.163
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000224
Scope note: An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.
Allowable Qualifiers: BL blood
CF cerebrospinal fluid
CI chemically induced
CL classification
CN congenital
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SU surgery
TH therapy
UR urine
VE veterinary
VI virology
Public MeSH Note: 2005; see ADDISON'S DISEASE 1966-2004
History Note: 2005 (1963)
Entry Version: ADDISON DIS
DeCS ID: 232
Unique ID: D000224
NLM Classification: WK 765
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1960/01/01
Date of Entry: 1999/01/01
Revision Date: 2012/07/03
Addison Disease - Preferred
Concept UI M0000346
Scope note An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.
Preferred term Addison Disease
Entry term(s) Addison's Disease
Addisons Disease
Adrenal Insufficiency, Primary
Adrenocortical Insufficiencies, Primary
Adrenocortical Insufficiency, Primary
Disease, Addison
Hypoadrenalism, Primary
Hypoadrenalisms, Primary
Insufficiencies, Primary Adrenocortical
Insufficiency, Primary Adrenocortical
Primary Adrenal Insufficiency
Primary Adrenocortical Insufficiencies
Primary Adrenocortical Insufficiency
Primary Hypoadrenalism



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