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Descriptor English: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
Descriptor Spanish: Ácido 3-piridinacarboxílico, 1,4-dihidro-2,6-dimetil-5-nitro-4-(2-(trifluorometil)fenil)-, Éster Metílico
Descriptor Portuguese: Éster Metílico do Ácido 3-Piridinacarboxílico, 1,4-Di-Hidro-2,6-Dimetil-5-Nitro-4-(2-(Trifluormetil)fenil)
Descriptor French: 4-(2-(Trifluorométhyl)phényl)-2,6-diméthyl-5-nitro-1,4-dihydro-nicotinate de méthyle
Entry term(s): BK 8644
BK-8644
BK8644
Bay K 8644
Bay K8644
Bay R 5417
Bay R5417
Bay-K-8644
Bay-K-8644, (+)-Isomer
Bay-K-8644, (+-)-Isomer
Bay-K-8644, (-)-Isomer
Bay-K8644
Bay-R-5417
BayK8644
BayR5417
R5417, Bay
Tree number(s): D03.383.725.203.600
D03.383.725.547.900
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D001498
Scope note: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Annotation: a calcium channel agonist
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Calcium Channel Agonists
Registry Number: 71145-03-4
CAS Type 1 Name: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, methyl ester
Previous Indexing: Nifedipine/analogs & derivatives (1975-1986)
Pyridines (1966-1974)
Public MeSH Note: 87
History Note: 87
DeCS ID: 23220
Unique ID: D001498
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1986/06/02
Revision Date: 2016/05/27
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - Preferred
Concept UI M0002232
Scope note A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Preferred term 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
Bay-R-5417 - Narrower
Concept UI M0002233
Preferred term Bay-R-5417
Entry term(s) Bay R 5417
Bay R5417
BayR5417
R5417, Bay
Bay-K-8644, (+-)-Isomer - Narrower
Concept UI M0330828
Preferred term Bay-K-8644, (+-)-Isomer
Bay-K-8644, (-)-Isomer - Narrower
Concept UI M0330829
Preferred term Bay-K-8644, (-)-Isomer
Bay-K-8644 - Narrower
Concept UI M0464447
Preferred term Bay-K-8644
Entry term(s) BK 8644
BK-8644
BK8644
Bay K 8644
Bay K8644
Bay-K8644
BayK8644
Bay-K-8644, (+)-Isomer - Narrower
Concept UI M0330830
Preferred term Bay-K-8644, (+)-Isomer



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