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Descriptor English: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
Descriptor Spanish: Ácido 3-piridinacarboxílico, 1,4-dihidro-2,6-dimetil-5-nitro-4-(2-(trifluorometil)fenil)-, Éster Metílico
Descriptor ácido 3-piridinacarboxílico 1,4-dihidro-2,6-dimetil-5-nitro-4-(2-(trifluorometil)fenil) éster metílico
Entry term(s) metil éster del ácido 3-piridinacarboxílico, 1,4-dihidro-2,6-dimetil-5-nitro-4-(2-(trifluorometil)fenil
ácido 3-piridinacarboxílico, 1,4-dihidro-2,6-dimetil-5-nitro-4-(2-(trifluorometil)fenil)-, metil éster
éster metílico del ácido 3-piridinacarboxílico, 1,4-dihidro-2,6-dimetil-5-nitro-4-(2-(trifluorometil)fenil)
Scope note: Derivado de la dihidropiridina, el cual, en contraste con la NIFEDIPINA, actúa como agonista del canal del calcio. Este compuesto facilita la entrada de Ca2+ a través de los canales del calcio, dependientes de voltaje, parcialmente activados, causando vasoconstricción y efectos inotrópicos positivos. Se utiliza principalmente en investigación.
Descriptor Portuguese: Éster Metílico do Ácido 3-Piridinacarboxílico, 1,4-Di-Hidro-2,6-Dimetil-5-Nitro-4-(2-(Trifluormetil)fenil)
Descriptor French: 4-(2-(Trifluorométhyl)phényl)-2,6-diméthyl-5-nitro-1,4-dihydro-nicotinate de méthyle
Entry term(s): 4-(2-(Trifluorométhyl)phényl)-2,6-diméthyl-5-nitro-1,4-dihydro-pyridine-3-carboxylate de méthyle
4-(2-(Trifluorométhyl)phényl)-2,6-diméthyl-5-nitro-1,4-dihydronicotinate de méthyle
4-(2-(Trifluorométhyl)phényl)-2,6-diméthyl-5-nitro-1,4-dihydropyridine-3-carboxylate de méthyle
BK-8644
Bay K 8644
Bay R 5417
Bay R5417
Bay-K-8644
Bay-K8644
Bay-R-5417
BayK8644
BayR5417
Isomère (+) du Bay K 8644
Isomère (-) du Bay K 8644
Tree number(s): D03.383.725.203.600
D03.383.725.547.900
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D001498
Scope note: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Annotation: a calcium channel agonist
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Pharm Action: Calcium Channel Agonists
Registry Number: 71145-03-4
CAS Type 1 Name: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, methyl ester
DeCS ID: 23220
Unique ID: D001498
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1986/06/02
Revision Date: 2016/05/27
4-(2-(Trifluorométhyl)phényl)-2,6-diméthyl-5-nitro-1,4-dihydro-nicotinate de méthyle - Preferred
Concept UI M0002232
Preferred term 4-(2-(Trifluorométhyl)phényl)-2,6-diméthyl-5-nitro-1,4-dihydro-nicotinate de méthyle
Entry term(s) 4-(2-(Trifluorométhyl)phényl)-2,6-diméthyl-5-nitro-1,4-dihydro-pyridine-3-carboxylate de méthyle
4-(2-(Trifluorométhyl)phényl)-2,6-diméthyl-5-nitro-1,4-dihydronicotinate de méthyle
4-(2-(Trifluorométhyl)phényl)-2,6-diméthyl-5-nitro-1,4-dihydropyridine-3-carboxylate de méthyle
Bay R 5417 - Narrower
Concept UI M0002233
Preferred term Bay R 5417
Entry term(s) Bay R5417
Bay-R-5417
BayR5417
Isomère (-) du Bay K 8644 - Narrower
Concept UI M0330829
Preferred term Isomère (-) du Bay K 8644
Bay K 8644 - Narrower
Concept UI M0464447
Preferred term Bay K 8644
Entry term(s) BK-8644
Bay-K-8644
Bay-K8644
BayK8644
Isomère (+) du Bay K 8644 - Narrower
Concept UI M0330830
Preferred term Isomère (+) du Bay K 8644



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