Search
Descriptor English: Chloramphenicol O-Acetyltransferase
Descriptor Spanish: Cloranfenicol O-Acetiltransferasa
Descriptor cloramfenicol O-acetiltransferasa
Entry term(s) cloranfenicol acetiltransferasa
enzima CAT
Scope note: Enzima que cataliza la acetilación del cloranfenicol dando lugar a cloranfenicol 3-acetato. Como el cloranfenicol 3-acetato no se une a los ribosomas bacterianos y no es un inhibidor de peptidiltransferasa, la enzima es la responsable de la resistencia natural de las bacterias al cloranfenicol. La enzima, de la que se conocen variantes, está presente en bacterias gramnegativas y grampositivas. EC 2.3.1.28.
Descriptor Portuguese: Cloranfenicol O-Acetiltransferase
Descriptor French: Chloramphenicol O-acetyltransferase
Entry term(s): Acetyltransferase, Chloramphenicol
CAT Enzyme
Chloramphenicol Acetyltransferase
Chloramphenicol O Acetyltransferase
Chloramphenicol Transacetylase
Enzyme, CAT
O-Acetyltransferase, Chloramphenicol
Transacetylase, Chloramphenicol
Tree number(s): D08.811.913.050.134.170
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015500
Scope note: An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.3.1.28
CAS Type 1 Name: Acetyl-CoA-chloramphenicol 3-O-acetyltransferase
Previous Indexing: Acetyltransferases (1973-1988)
Transferases (1966-1972)
Public MeSH Note: 98(89); see CHLORAMPHENICOL ACETYLTRANSFERASE 1989-97
History Note: 98(89)
Related: Chloramphenicol Resistance MeSH
DeCS ID: 23584
Unique ID: D015500
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/07/13
Revision Date: 2003/07/09
Chloramphenicol O-Acetyltransferase - Preferred
Concept UI M0023862
Scope note An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
Preferred term Chloramphenicol O-Acetyltransferase
Entry term(s) Acetyltransferase, Chloramphenicol
CAT Enzyme
Chloramphenicol Acetyltransferase
Chloramphenicol O Acetyltransferase
Chloramphenicol Transacetylase
Enzyme, CAT
O-Acetyltransferase, Chloramphenicol
Transacetylase, Chloramphenicol



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.

Go to survey