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Descriptor English: Phorbol 12,13-Dibutyrate
Descriptor Spanish: Forbol 12,13-Dibutirato
Descriptor forbol 12,13-dibutirato
Scope note: Éster de forbol que se encuentra en el ACEITE DE CROTONA que, además de ser un potente promotor de tumores cutáneos, es también un activador eficaz de la proteína cinasa dependiente de fosfolípidos y activada por calcio (proteína cinasa C). Debido a la activación de esta enzima, el forbol 12,13-dibutirato afecta profundamente a muchos sistemas biológicos diferentes.
Descriptor Portuguese: Dibutirato de 12,13-Forbol
Descriptor French: 12,13-Dibutyrate de phorbol
Entry term(s): 12,13-Dibutyrate, Phorbol
Phorbol 12,13 Dibutyrate
Phorbol-12,13-Dibutyrate
Tree number(s): D02.455.849.291.500.510.700
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015240
Scope note: A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AN analysis
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
Pharm Action: Carcinogens
Registry Number: 37558-16-0
CAS Type 1 Name: Butanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diyl ester, (1aR-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha))-
Previous Indexing: Phorbol Esters (1979-1988)
Public MeSH Note: 89
History Note: 89
Entry Version: PDBU
DeCS ID: 23798
Unique ID: D015240
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/05/14
Revision Date: 2004/07/30
Phorbol 12,13-Dibutyrate - Preferred
Concept UI M0023428
Scope note A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.
Preferred term Phorbol 12,13-Dibutyrate
Entry term(s) 12,13-Dibutyrate, Phorbol
Phorbol 12,13 Dibutyrate
Phorbol-12,13-Dibutyrate



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