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Descriptor English: Fusaric Acid
Descriptor Spanish: Ácido Fusárico
Descriptor ácido fusárico
Scope note: Derivado del ácido picolínico, que se extrae de diversas especies de Fusarium. Se ha propuesto para muy diversas aplicaciones, aunque su principal utilización es en investigación. Sus mecanismos de acción son poco conocidos. Probablemente inhibe la DOPAMINA BETA-HIDROXILASA, la enzima que convierte la dopamina en norepinefrina. También tiene otras acciones, entre las que se incluye la inhibición de la proliferación celular y la síntesis de ADN.
Descriptor Portuguese: Ácido Fusárico
Descriptor French: Acide fusarique
Entry term(s): 5 Butyl 2 pyridinedicarboxylic Acid
5-Butyl-2-pyridinedicarboxylic Acid
Acid, 5-Butyl-2-pyridinedicarboxylic
Acid, Fusaric
Calcium Fusarate
Fusarate, Calcium
Tree number(s): D03.066.707.200
D03.383.725.705.200
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005669
Scope note: A picolinic acid derivative isolated from various Fusarium species. It has been proposed for a variety of therapeutic applications but is primarily used as a research tool. Its mechanisms of action are poorly understood. It probably inhibits DOPAMINE BETA-HYDROXYLASE, the enzyme that converts dopamine to norepinephrine. It may also have other actions, including the inhibition of cell proliferation and DNA synthesis.
Annotation: /biosyn permitted if by organism
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Enzyme Inhibitors
Dopamine Agents
Nucleic Acid Synthesis Inhibitors
Registry Number: JWJ963070N
CAS Type 1 Name: 2-Pyridinecarboxylic acid, 5-butyl-
Previous Indexing: Picolinic Acids (1969-1974)
Public MeSH Note: 91; was see under PICOLINIC ACIDS 1975-90
History Note: 91(75); was see under PICOLINIC ACIDS 1975-90
DeCS ID: 24003
Unique ID: D005669
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2016/05/31
Fusaric Acid - Preferred
Concept UI M0008907
Scope note A picolinic acid derivative isolated from various Fusarium species. It has been proposed for a variety of therapeutic applications but is primarily used as a research tool. Its mechanisms of action are poorly understood. It probably inhibits DOPAMINE BETA-HYDROXYLASE, the enzyme that converts dopamine to norepinephrine. It may also have other actions, including the inhibition of cell proliferation and DNA synthesis.
Preferred term Fusaric Acid
Entry term(s) 5 Butyl 2 pyridinedicarboxylic Acid
5-Butyl-2-pyridinedicarboxylic Acid
Acid, 5-Butyl-2-pyridinedicarboxylic
Acid, Fusaric
Calcium Fusarate - Narrower
Concept UI M0008906
Preferred term Calcium Fusarate
Entry term(s) Fusarate, Calcium



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