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Descriptor English: Levodopa
Descriptor Spanish: Levodopa
Descriptor levodopa
Entry term(s) L-dopa
Scope note: La forma natural de DIHIDROXIFENILALANINA, precursor inmediato de la DOPAMINA. A diferencia de la dopamina, puede ser adminstrada por vía ora yl cruza la barrera hematoencefálica. Es rápidamente captada por las neuronas dopaminérgicas y convertida en DOPAMINA. Se utiliza en el tratamiento de los TRASTORNOS PARKINSONIANOS y se administra usualmente con agentes que inhiben su conversión a dopamina fuera del sistema nervioso central.
Descriptor Portuguese: Levodopa
Descriptor French: Lévodopa
Entry term(s): 3 Hydroxy L tyrosine
3-Hydroxy-L-tyrosine
Dopaflex
Dopar
L 3,4 Dihydroxyphenylalanine
L Dopa
L-3,4-Dihydroxyphenylalanine
L-Dopa
Larodopa
Levopa
Tree number(s): D02.092.311.200.480
D02.455.426.559.389.657.166.175.200.480
D12.125.072.050.685.400.500
D12.125.072.050.875.130.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007980
Scope note: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antiparkinson Agents
Dopamine Agents
Registry Number: 46627O600J
Previous Indexing: Dopa (1966-1974)
Public MeSH Note: 75; was see DOPA 1972-74
Online Note: search DOPA 1972-74
History Note: 75; was see DOPA 1972-74
Related: Dopamine MeSH
DeCS ID: 24230
Unique ID: D007980
NLM Classification: WK 725
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1975/01/01
Date of Entry: 1999/01/01
Revision Date: 2018/06/30
Levodopa - Preferred
Concept UI M0012434
Scope note The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.
Preferred term Levodopa
Entry term(s) 3 Hydroxy L tyrosine
3-Hydroxy-L-tyrosine
L 3,4 Dihydroxyphenylalanine
L Dopa
L-3,4-Dihydroxyphenylalanine
L-Dopa
Levopa - Narrower
Concept UI M0351195
Preferred term Levopa
Larodopa - Narrower
Concept UI M0012435
Preferred term Larodopa
Dopaflex - Narrower
Concept UI M0463388
Preferred term Dopaflex
Dopar - Narrower
Concept UI M0463389
Preferred term Dopar



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