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Descriptor English: Substance P
Descriptor Spanish: Sustancia P
Descriptor sustancia P
Scope note: Neurotransmisor de 11 aminoácidos que aparece tanto en el sistema nervioso central como en el sistema nervioso periférico. Está implicado en la transmisión del DOLOR, produce contracciones rápidas del músculo liso gastrointestinal y modula las respuestas inflamatorias e inmunitarias.
Descriptor Portuguese: Substância P
Descriptor French: Substance P
Entry term(s): Euler Gaddum Substance P
Euler-Gaddum Substance P
Hypothalamic Substance P
SP(1-11)
Substance P, Euler-Gaddum
Substance P, Hypothalamic
Tree number(s): D12.644.276.812.900.866
D12.644.400.800.750
D12.644.456.800.866
D12.776.467.812.900.866
D12.776.631.650.800.750
D23.469.050.375.850.890
D23.529.812.900.866
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013373
Scope note: An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Neurotransmitter Agents
Registry Number: 33507-63-0
Public MeSH Note: 73; was see under PEPTIDES 1963-72; EULER-GADDUM SUBSTANCE P was see SUBSTANCE P 1973-92; HYPOTHALAMIC SUBSTANCE P was see SUBSTANCE P 1977-92
Online Note: use SUBSTANCE P to search EULER-GADDUM SUBSTANCE P 1973-92 & HYPOTHALAMIC SUBSTANCE P 1977-92
History Note: 73(65); was see under PEPTIDES 1963-72; EULER-GADDUM SUBSTANCE P was see SUBSTANCE P 1973-92; HYPOTHALAMIC SUBSTANCE P was see SUBSTANCE P 1977-92
Related: Receptors, Neurokinin-1 MeSH
DeCS ID: 24334
Unique ID: D013373
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/05
Substance P - Preferred
Concept UI M0020674
Scope note An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.
Preferred term Substance P
Entry term(s) Euler Gaddum Substance P
Euler-Gaddum Substance P
SP(1-11)
Substance P, Euler-Gaddum
Hypothalamic Substance P - Narrower
Concept UI M0020675
Preferred term Hypothalamic Substance P
Entry term(s) Substance P, Hypothalamic



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