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Descriptor English: Complement C4b
Descriptor Spanish: Complemento C4b
Descriptor complemento C4b
Scope note: El fragmento grande formado cuando el COMPLEMENTO C4 es desdoblado por el COMPLEMENTO C1S. El C4b unido a la membrana se une al COMPLEMENTO C2A, una SERINA PROTEASA, para formar C4b2a (CONVERTASA C3 DE LA VÍA CLÁSICA) y posteriormente C4b2a3b (CONVERTASA C5 DE LA VÍA CLÁSICA).
Descriptor Portuguese: Complemento C4b
Descriptor French: Complément C4b
Entry term(s): C4b Complement
C4b, Complement
Complement 4b
Complement Component 4b
Complement, C4b
Component 4b, Complement
Tree number(s): D12.776.124.486.274.350.260
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015935
Scope note: The large fragment formed when COMPLEMENT C4 is cleaved by COMPLEMENT C1S. The membrane-bound C4b binds COMPLEMENT C2A, a SERINE PROTEASE, to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Registry Number: 80295-50-7
CAS Type 1 Name: Complement C4b
Previous Indexing: Complement 4 (1975-1989)
Public MeSH Note: 2006; see COMPLEMENT 4B 1990-2005
History Note: 2006 (1990)
DeCS ID: 24579
Unique ID: D015935
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2005/06/30
Complement C4b - Preferred
Concept UI M0024380
Scope note The large fragment formed when COMPLEMENT C4 is cleaved by COMPLEMENT C1S. The membrane-bound C4b binds COMPLEMENT C2A, a SERINE PROTEASE, to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).
Preferred term Complement C4b
Entry term(s) C4b Complement
C4b, Complement
Complement 4b
Complement Component 4b
Complement, C4b
Component 4b, Complement



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