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Descriptor English: Factor VIIIa
Descriptor Spanish: Factor VIIIa
Descriptor factor VIIIa
Entry term(s) factor 8A
factor VIII activado
factor VIII activado por trombina
factor VIIIa de la coagulación
factor ocho A
Scope note: Forma activada del factor VIII. El dominio B del factor VIII es desdoblado proteolíticamente por la trombina para formar el factor VIIIa. El factor VIIIa existe como dímero no covalente en un complejo de unión metálica (probablemente calcio) y funciona como cofactor en la activación enzimática del factor X por el factor IXa. El factor VIII tiene una estructura y generación similares al factor Va.
Descriptor Portuguese: Fator VIIIa
Descriptor French: Facteur VIIIa
Entry term(s): Activated Factor VIII
Blood Coagulation Factor VIII, Activated
Coagulation Factor VIIIa
Factor 8A
Factor Eight A
Factor VIII, Activated
Factor VIII, Thrombin Activated
Factor VIII, Thrombin-Activated
Factor VIIIa Heavy Chain, 200 kDa Isoform
Factor VIIIa Heavy Chain, 92 kDa Isoform
Factor VIIIa Light Chain
Factor VIIIa, Coagulation
Thrombin-Activated Factor VIII
Tree number(s): D12.776.124.125.350.300
D23.119.350.300
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015944
Scope note: Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Hemophilia A
Registry Number: 72175-66-7
CAS Type 1 Name: Blood-coagulation factor VIIIa, procoagulant
Previous Indexing: Factor VIII (1981-1989)
Public MeSH Note: 90
History Note: 90
Related: Coagulants MeSH
DeCS ID: 24644
Unique ID: D015944
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2017/02/24
Factor VIIIa - Preferred
Concept UI M0024392
Scope note Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.
Preferred term Factor VIIIa
Entry term(s) Activated Factor VIII
Blood Coagulation Factor VIII, Activated
Coagulation Factor VIIIa
Factor 8A
Factor Eight A
Factor VIII, Activated
Factor VIII, Thrombin Activated
Factor VIII, Thrombin-Activated
Factor VIIIa, Coagulation
Thrombin-Activated Factor VIII
Factor VIIIa Light Chain - Narrower
Concept UI M0542859
Preferred term Factor VIIIa Light Chain
Factor VIIIa Heavy Chain, 200 kDa Isoform - Narrower
Concept UI M0542857
Preferred term Factor VIIIa Heavy Chain, 200 kDa Isoform
Factor VIIIa Heavy Chain, 92 kDa Isoform - Narrower
Concept UI M0542858
Preferred term Factor VIIIa Heavy Chain, 92 kDa Isoform



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