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Descriptor English: Giant Cells
Descriptor Spanish: Células Gigantes
Descriptor Portuguese: Células Gigantes
Descriptor French: Cellules géantes
Entry term(s): Cell, Giant
Cell, Multinucleated Giant
Cells, Giant
Cells, Multinucleated Giant
Giant Cell
Giant Cell, Multinucleated
Giant Cells, Multinucleated
Multinucleated Giant Cell
Multinucleated Giant Cells
Polykaryocyte
Polykaryocytes
Syncytia
Syncytium
Tree number(s): A11.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015726
Scope note: Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.
Allowable Qualifiers: CH chemistry
CL classification
CY cytology
DE drug effects
EN enzymology
IM immunology
ME metabolism
MI microbiology
PA pathology
PH physiology
PS parasitology
RE radiation effects
TR transplantation
UL ultrastructure
VI virology
Previous Indexing: Cell Fusion (1972-1989)
Public MeSH Note: 90
History Note: 90
DeCS ID: 24694
Unique ID: D015726
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/04/07
Revision Date: 2011/06/24
Giant Cells - Preferred
Concept UI M0024113
Scope note Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.
Preferred term Giant Cells
Entry term(s) Cell, Giant
Cell, Multinucleated Giant
Cells, Giant
Cells, Multinucleated Giant
Giant Cell
Giant Cell, Multinucleated
Giant Cells, Multinucleated
Multinucleated Giant Cell
Multinucleated Giant Cells
Polykaryocyte
Polykaryocytes
Syncytia
Syncytium



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