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Descriptor English: Inositol 1,4,5-Trisphosphate
Descriptor Spanish: Inositol 1,4,5-Trifosfato
Descriptor inositol 1,4,5-trifosfato
Entry term(s) 1,4,5-InsP3
mioinositol 1,4,5-trifosfato
mioinositol 1,4,5-trisfosfato
Scope note: Mensajero intracelular producido por la acción de la fosfolipasa C sobre el fosfatidilinositol 4,5-bifosfato, el cual es uno de los fosfolípidos que forman la membrana celular. El inositol 1,4,5-trifosfato es liberado al citoplasma donde libera iones calcio de los depósitos intracelulares en el retículo endoplásmico. Estos iones calcio estimulan la actividad de la cinasa B o calmodulina.
Descriptor Portuguese: Inositol 1,4,5-Trifosfato
Descriptor French: Inositol 1,4,5-trisphosphate
Entry term(s): 1,4,5-IP3
1,4,5-InsP3
Inositol 1,4,5-Triphosphate
Myo-Inositol 1,4,5-Trisphosphate
Myoinositol 1,4,5-Triphosphate
Tree number(s): D02.033.800.519.400.350
D09.853.519.400.350
D09.894.480.350
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015544
Scope note: Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Registry Number: 85166-31-0
CAS Type 1 Name: D-myo-Inositol, 1,4,5-tris(dihydrogen phosphate)
Previous Indexing: Inositol Phosphates (1978-1989)
Sugar Phosphates (1974-1977)
Public MeSH Note: 90
History Note: 90
DeCS ID: 24744
Unique ID: D015544
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/07/05
Revision Date: 2004/07/07
Inositol 1,4,5-Trisphosphate - Preferred
Concept UI M0023913
Scope note Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.
Preferred term Inositol 1,4,5-Trisphosphate
Entry term(s) 1,4,5-IP3
1,4,5-InsP3
Inositol 1,4,5-Triphosphate
Myo-Inositol 1,4,5-Trisphosphate
Myoinositol 1,4,5-Triphosphate



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