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Descriptor English: Chloramphenicol
Descriptor Spanish: Cloranfenicol
Descriptor cloranfenicol
Entry term(s) levomicetina
Scope note: Antibiótico inicialmente aislado de cultivos de Streptomyces venequelae en 1947 que actualmente se produce de forma sintética. Tiene una estructura relativamente simple y fue el primer antibiótico de amplio espectro. Actua por interferencia con la síntesis proteica bacteriana y es principalmente bacteriostático. (Martindale, The Extra Pharmacopoeia, 29th ed, p106).
Descriptor Portuguese: Cloranfenicol
Descriptor French: Chloramphénicol
Entry term(s): Amphenicol
Amphenicols
Chlornitromycin
Chlorocid
Chloromycetin
Cloranfenicol
Detreomycin
Kloramfenikol
Levomycetin
Ophthochlor
Syntomycin
Tree number(s): D02.033.455.706.300
D02.455.426.559.389.565.175
D02.640.529.175
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002701
Scope note: An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
Annotation: an antibiotic
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Bacterial Agents
Protein Synthesis Inhibitors
Registry Number: 66974FR9Q1
CAS Type 1 Name: Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (R-(R*,R*))-
DeCS ID: 2747
Unique ID: D002701
NLM Classification: QV 350.5.C5
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2018/07/02
Chloramphenicol - Preferred
Concept UI M0004121
Scope note An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
Preferred term Chloramphenicol
Entry term(s) Cloranfenicol
Kloramfenikol
Chlornitromycin - Narrower
Concept UI M0004123
Preferred term Chlornitromycin
Chlorocid - Narrower
Concept UI M0004124
Preferred term Chlorocid
Amphenicol - Broader
Concept UI M000642862
Scope note Chloramphenicol and its derivatives.
Preferred term Amphenicol
Entry term(s) Amphenicols
Ophthochlor - Narrower
Concept UI M0004126
Preferred term Ophthochlor
Syntomycin - Narrower
Concept UI M0004127
Preferred term Syntomycin
Levomycetin - Narrower
Concept UI M0004128
Preferred term Levomycetin
Chloromycetin - Narrower
Concept UI M0004122
Preferred term Chloromycetin
Detreomycin - Narrower
Concept UI M0004125
Preferred term Detreomycin



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