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Descriptor in English: Sulindac
Descriptor in Spanish: Sulindac
Descriptor in Portuguese: Sulindaco
Descriptor in French: Sulindac
Entry term(s): Aclin
Apo Sulin
Apo-Sulin
Arthrobid
Arthrocine
Chibret
Clinoril
Copal
Kenalin
Klinoril
MK 231
MK-231
MK231
Novo Sundac
Novo-Sundac
Nu Sulindac
Nu-Sulindac
Sulindal
Tree number(s): D02.455.426.559.847.486.875
D04.615.486.875
Scope note: A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 90(79); was see under INDENES 1979-89
DeCS UI: 27862
Descriptor UI: D013467
Date Established: 1990/01/01
Date of Entry: 1978/02/08
Revision Date: 2016/07/01
Sulindac - Preferred
Concept UI M0020810
Scope note A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Preferred term Sulindac
Apo-Sulin - Narrower
Concept UI M0476024
Preferred term Apo-Sulin
Entry term(s) Apo Sulin
Arthrobid - Narrower
Concept UI M0350601
Preferred term Arthrobid
Clinoril - Narrower
Concept UI M0020811
Preferred term Clinoril
Entry term(s) Arthrocine
Klinoril
Sulindal - Narrower
Concept UI M0476029
Preferred term Sulindal
Entry term(s) Chibret
Kenalin - Narrower
Concept UI M0476026
Preferred term Kenalin
MK-231 - Narrower
Concept UI M0350641
Preferred term MK-231
Entry term(s) MK 231
MK231
Novo-Sundac - Narrower
Concept UI M0476027
Preferred term Novo-Sundac
Entry term(s) Novo Sundac
Nu-Sulindac - Narrower
Concept UI M0476028
Preferred term Nu-Sulindac
Entry term(s) Nu Sulindac
Aclin - Narrower
Concept UI M0476023
Preferred term Aclin
Copal - Narrower
Concept UI M0476025
Preferred term Copal



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