Descriptor in English: | Sulindac |
Descriptor in Spanish: | Sulindac |
Descriptor in Portuguese: | Sulindaco |
Descriptor in French: | Sulindac |
Entry term(s): |
Aclin Apo Sulin Apo-Sulin Arthrobid Arthrocine Chibret Clinoril Copal Kenalin Klinoril MK 231 MK-231 MK231 Novo Sundac Novo-Sundac Nu Sulindac Nu-Sulindac Sulindal |
Tree number(s): |
D02.455.426.559.847.486.875 D04.615.486.875 |
Scope note: | A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects. |
Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
History Note: | 90(79); was see under INDENES 1979-89 |
DeCS UI: | 27862 |
Descriptor UI: | D013467 |
Date Established: | 1990/01/01 |
Date of Entry: | 1978/02/08 |
Revision Date: | 2016/07/01 |
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CHEMICALS AND DRUGS
Organic Chemicals [D02]Organic Chemicals -
CHEMICALS AND DRUGS
Polycyclic Compounds [D04]Polycyclic Compounds
|
Sulindac
- Preferred
Apo-Sulin
- Narrower
Arthrobid
- Narrower
Clinoril
- Narrower
Sulindal
- Narrower
Kenalin
- Narrower
MK-231
- Narrower
Novo-Sundac
- Narrower
Nu-Sulindac
- Narrower
Aclin
- Narrower
Copal
- Narrower
Concept UI |
M0020810 |
Scope note | A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects. |
Preferred term | Sulindac |
Concept UI |
M0476024 |
Preferred term | Apo-Sulin |
Entry term(s) |
Apo Sulin |
Concept UI |
M0350601 |
Preferred term | Arthrobid |
Concept UI |
M0020811 |
Preferred term | Clinoril |
Entry term(s) |
Arthrocine Klinoril |
Concept UI |
M0476029 |
Preferred term | Sulindal |
Entry term(s) |
Chibret |
Concept UI |
M0476026 |
Preferred term | Kenalin |
Concept UI |
M0350641 |
Preferred term | MK-231 |
Entry term(s) |
MK 231 MK231 |
Concept UI |
M0476027 |
Preferred term | Novo-Sundac |
Entry term(s) |
Novo Sundac |
Concept UI |
M0476028 |
Preferred term | Nu-Sulindac |
Entry term(s) |
Nu Sulindac |
Concept UI |
M0476023 |
Preferred term | Aclin |
Concept UI |
M0476025 |
Preferred term | Copal |
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