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Descriptor English: Antithrombins
Descriptor Spanish: Antitrombinas
Descriptor antitrombinas
Entry term(s) antitrombina
antitrombina directa
antitrombinas directas
inhibidor directo de la trombina
Scope note: Familia de proteínas endógenas que pertenecen a la superfamilia de la serpina que neutraliza la acción de la trombina. Se han identificado seis antitrombinas naturales, a las que se ha designado con números romanos del I al VI. Las que mayor importancia parecen tener son la antitrombina I (ver FIBRINA) y ANTITROMBINA III.
Descriptor Portuguese: Antitrombinas
Descriptor French: Antithrombiniques
Entry term(s): Antithrombin
Antithrombin, Direct
Antithrombins, Direct
Direct Antithrombin
Direct Antithrombins
Direct Thrombin Inhibitor
Direct Thrombin Inhibitors
Inhibitor, Direct Thrombin
Thrombin Inhibitor, Direct
Thrombin Inhibitors, Direct
Tree number(s): D27.505.519.389.745.800.449
D27.505.954.502.119.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000991
Scope note: Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.
Annotation: ANTITHROMBIN PROTEINS is also available
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Public MeSH Note: see ANTITHROMBIN 1964-1966
History Note: 2011(1964)
DeCS ID: 27917
Unique ID: D000991
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1967/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27
Antithrombins - Preferred
Concept UI M0544738
Scope note Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.
Preferred term Antithrombins
Entry term(s) Antithrombin
Antithrombin, Direct
Antithrombins, Direct
Direct Antithrombin
Direct Antithrombins
Direct Thrombin Inhibitor
Direct Thrombin Inhibitors
Inhibitor, Direct Thrombin
Thrombin Inhibitor, Direct
Thrombin Inhibitors, Direct



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