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Descriptor English: Dosage Compensation, Genetic
Descriptor Spanish: Compensación de Dosificación (Genética)
Descriptor compensación de dosis genética
Entry term(s) compensación de dosificación genética
Scope note: Mecanismos genéticos que permiten que los GENES se expresen de una forma similar independientemente de la DOSIFICACIÓN GÉNICA. Este término se suele utilizar en relación con los genes localizados en los CROMOSOMAS SEXUALES. Como los cromosomas sexuales son sólo parcialmente homólogos hay un número de copias, es decir de dosificación, diferente en los varones y hembras. En DROSOPHILA la compensación de la dosificación se lleva a cabo mediante hipertranscripción de los genes localizados en el CROMOSOMA X. En los mamíferos la compensación de la dosificación de los genes del cromosoma X se realiza mediante INACTIVACIÓN DEL CROMOSOMA X aleatoria de uno de los dos cromosomas X de la mujer.
Descriptor Portuguese: Mecanismo Genético de Compensação de Dose
Descriptor French: Compensation de dosage génétique
Entry term(s): Compensation, Dosage (Genetics)
Compensation, Gene Dosage
Compensation, Genetic Dosage
Dosage Compensation (Genetics)
Dosage Compensation, Gene
Gene Dosage Compensation
Gene Dosage Compensations
Genetic Dosage Compensation
Genetic Dosage Compensations
Hypertranscription, X Chromosome
Hypertranscription, X-Chromosome
X Chromosome Hypertranscription
X-Chromosome Hypertranscription
Tree number(s): G05.308.203.249
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004303
Scope note: Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing genes that lie on the SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there is a different copy number, i.e., dosage, of these genes in males vs. females. In DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.
Annotation: do not confuse with GENE DOSAGE
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Sex Chromosomes (1968-1981)
X Chromosome (1978-1981)
Public MeSH Note: 2006; see DOSAGE COMPENSATION (GENETICS) 1982-2005
History Note: 2006 (1982)
DeCS ID: 27989
Unique ID: D004303
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1982/01/01
Date of Entry: 1981/02/23
Revision Date: 2016/06/17
Dosage Compensation, Genetic - Preferred
Concept UI M0006764
Scope note Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing genes that lie on the SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there is a different copy number, i.e., dosage, of these genes in males vs. females. In DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.
Preferred term Dosage Compensation, Genetic
Entry term(s) Compensation, Dosage (Genetics)
Compensation, Gene Dosage
Compensation, Genetic Dosage
Dosage Compensation (Genetics)
Dosage Compensation, Gene
Gene Dosage Compensation
Gene Dosage Compensations
Genetic Dosage Compensation
Genetic Dosage Compensations
X-Chromosome Hypertranscription - Narrower
Concept UI M0485273
Preferred term X-Chromosome Hypertranscription
Entry term(s) Hypertranscription, X Chromosome
Hypertranscription, X-Chromosome
X Chromosome Hypertranscription



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