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Descriptor English: Formyltetrahydrofolates
Descriptor Spanish: Formiltetrahidrofolatos
Descriptor Portuguese: Formiltetra-Hidrofolatos
Descriptor French: Formyltétrahydrofolates
Entry term(s): Formyltetrahydrofolic Acids
N(10)-Formyltetrahydrofolate
Tree number(s): D03.633.100.733.631.400.800.350
D08.211.840.300
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005575
Scope note: Tetrahydrofolates which are substituted by a formyl group at either the nitrogen atom in the 5 position or the nitrogen atom in the 10 position. N(5)-Formyltetrahydrofolate is leucovorin (citrovorum factor) while N(10)-formyltetrahydrofolate is an active coenzyme which functions as a carrier of the formyl group in a number of enzymatic reactions.
Annotation: deficiency: coordinate FORMYLTETRAHYDROFOLATES /defic (IM) with FOLIC ACID DEFICIENCY (IM)
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Vitamin B Complex
Previous Indexing: Citrovorum Factor (1966-1975)
Public MeSH Note: 1991; FORMYLTETRAHYDROFOLATES was indexed under TETRAHYDROFOLATES 1976-1990
History Note: 1991 (1976)
DeCS ID: 28042
Unique ID: D005575
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1975/07/25
Revision Date: 2018/02/27
Formyltetrahydrofolates - Preferred
Concept UI M0008775
Scope note Tetrahydrofolates which are substituted by a formyl group at either the nitrogen atom in the 5 position or the nitrogen atom in the 10 position. N(5)-Formyltetrahydrofolate is leucovorin (citrovorum factor) while N(10)-formyltetrahydrofolate is an active coenzyme which functions as a carrier of the formyl group in a number of enzymatic reactions.
Preferred term Formyltetrahydrofolates
Formyltetrahydrofolic Acids - Related but not broader or narrower
Concept UI M000638461
Preferred term Formyltetrahydrofolic Acids
N(10)-Formyltetrahydrofolate - Narrower
Concept UI M0008776
Preferred term N(10)-Formyltetrahydrofolate



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