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Descriptor English: Macrophage-Activating Factors
Descriptor Spanish: Factores Activadores de Macrófagos
Descriptor factores activadores de macrófagos
Scope note: Factores segregados por linfocitos estimulados que preparan a los macrófagos para que se conviertan en citotóxicos inespecíficos para los tumores. También modulan la expresión de los antígenos Ia de la superficie celular de los macrófagos. Un FAM es el INTERFERÓN GAMMA. También se han identificado otros factores antigénicamente diferentes al IFN-gamma.
Descriptor Portuguese: Fatores Ativadores de Macrófagos
Descriptor French: Facteurs d'activation des macrophages
Entry term(s): Factors, Macrophage-Activating
Macrophage Activating Factors
Tree number(s): D12.644.276.374.480.615
D12.776.467.374.480.615
D23.529.374.480.615
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016215
Scope note: Factors secreted by stimulated lymphocytes that prime macrophages to become nonspecifically cytotoxic to tumors. They also modulate the expression of macrophage cell surface Ia antigens. One MAF is INTERFERON-GAMMA. Other factors antigenically distinct from IFN-gamma have also been identified.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Lymphokines (1976-1990)
Public MeSH Note: 91
History Note: 91
Entry Version: MAF
DeCS ID: 29033
Unique ID: D016215
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1990/04/24
Revision Date: 2008/07/10
Macrophage-Activating Factors - Preferred
Concept UI M0024763
Scope note Factors secreted by stimulated lymphocytes that prime macrophages to become nonspecifically cytotoxic to tumors. They also modulate the expression of macrophage cell surface Ia antigens. One MAF is INTERFERON-GAMMA. Other factors antigenically distinct from IFN-gamma have also been identified.
Preferred term Macrophage-Activating Factors
Entry term(s) Factors, Macrophage-Activating
Macrophage Activating Factors



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