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Descriptor English: Methacholine Chloride
Descriptor Spanish: Cloruro de Metacolina
Descriptor cloruro de metacolina
Entry term(s) metacolina
Scope note: Agente de amonio cuaternario, parasimpaticomimético, con las acciones muscarínicas de la ACETILCOLINA. Es hidrolizado por la ACETILCOLINESTERASA a una velocidad considerablemente menor que la ACETILCOLINA y es más resistente a la hidrólisis por COLINESTERASAS no específicas, por lo que sus acciones son más prolongadas. Se utiliza como broncoconstrictor parasimpáticomimético y como auxiliar diagnóstico en el asma bronquial (Martindale, The Extra Pharmacopoeia, 30th ed, p1116).
Descriptor Portuguese: Cloreto de Metacolina
Descriptor French: Chlorure de méthacholine
Entry term(s): 2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium Chloride
Acetyl 2 methylcholine Chloride
Acetyl beta methacholine Chloride
Acetyl beta methylcholine
Acetyl-2-methylcholine Chloride
Acetyl-beta-methacholine Chloride
Acetyl-beta-methylcholine
Chloride, Methacholine
Mecholine
Mecholyl
Methacholine
Provocholine
Provokit
Tree number(s): D02.092.877.883.555.500
D02.675.276.534.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016210
Scope note: A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Miotics
Parasympathomimetics
Bronchoconstrictor Agents
Muscarinic Agonists
Registry Number: 0W5ETF9M2K
CAS Type 1 Name: 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride
Previous Indexing: Methacholine Compounds (1966-1990)
Public MeSH Note: 91
History Note: 91
DeCS ID: 29044
Unique ID: D016210
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1990/04/24
Revision Date: 2016/07/01
Methacholine Chloride - Preferred
Concept UI M0024753
Scope note A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
Preferred term Methacholine Chloride
Entry term(s) 2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium Chloride
Acetyl 2 methylcholine Chloride
Acetyl beta methacholine Chloride
Acetyl-2-methylcholine Chloride
Acetyl-beta-methacholine Chloride
Chloride, Methacholine
Mecholine
Mecholyl - Broader
Concept UI M0024752
Preferred term Mecholyl
Provocholine - Narrower
Concept UI M0351161
Preferred term Provocholine
Provokit - Narrower
Concept UI M0474177
Preferred term Provokit
Acetyl-beta-methylcholine - Broader
Concept UI M0024754
Preferred term Acetyl-beta-methylcholine
Entry term(s) Acetyl beta methylcholine
Methacholine - Broader
Concept UI M0024755
Preferred term Methacholine



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