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Descriptor English: Calcimycin
Descriptor Spanish: Calcimicina
Descriptor calcimicina
Entry term(s) A-23187
A23187
antibiótico A23187
ionóforo cálcico A23187
ácido (6S-(6alfa(2S*,3S*),8beta(R*),9beta,11alfa))-5-(metilamino)-2-((3,9,11-trimetil-8-(1-metil-2-oxo-2-(1H-pirrol-2-il)etil)-1,7-dioxaspiro(5.5)undec-2-il)metil)-4-benzoxazolecarboxílico
Scope note: Antibiótico poliéter ionóforo obtenido de Streptomyces chartreusensis. Se une al CALCIO y a otros cationes divalentes y los transporta a través de las membranas y desacopla la fosforilación oxidativa mientras inhibe la ATPasa de las mitocondrias hepáticas del ratón. Esta sustancia se utiliza principalmente como herramienta bioquímica para estudiar el papel de los cationes divalentes en diversos sistemas biológicos.
Descriptor Portuguese: Calcimicina
Descriptor French: A-23187
Entry term(s): 4-Benzoxazolecarboxylic acid, 5-(methylamino)-2-((3,9,11-trimethyl-8-(1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-, (6S-(6alpha(2S*,3S*),8beta(R*),9beta,11alpha))-
A 23187
A-23187
A23187
A23187, Antibiotic
Antibiotic A23187
Tree number(s): D02.355.291.933.125
D02.540.576.625.125
D03.633.100.221.173
D04.345.241.654.125
D04.345.674.625.125
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000001
Scope note: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Bacterial Agents
Calcium Ionophores
Registry Number: 37H9VM9WZL
CAS Type 1 Name: 4-Benzoxazolecarboxylic acid, 5-(methylamino)-2-((3,9,11-trimethyl-8-(1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-, (6S-(6alpha(2S*,3S*),8beta(R*),9beta,11alpha))-
Previous Indexing: Antibiotics (1973-1974)
Carboxylic Acids (1973-1974)
Public MeSH Note: 91; was A 23187 1975-90 (see under ANTIBIOTICS 1975-83)
Online Note: use CALCIMYCIN to search A 23187 1975-90
History Note: 91(75); was A 23187 1975-90 (see under ANTIBIOTICS 1975-83)
DeCS ID: 29212
Unique ID: D000001
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1984/01/01
Date of Entry: 1974/11/19
Revision Date: 2016/05/27
Calcimycin - Preferred
Concept UI M0000001
Scope note An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.
Preferred term Calcimycin
Entry term(s) 4-Benzoxazolecarboxylic acid, 5-(methylamino)-2-((3,9,11-trimethyl-8-(1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-, (6S-(6alpha(2S*,3S*),8beta(R*),9beta,11alpha))-
A-23187 - Narrower
Concept UI M0353609
Preferred term A-23187
Entry term(s) A 23187
A23187
A23187, Antibiotic
Antibiotic A23187



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