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Descriptor English: Polyether Polyketides
Descriptor Spanish: Policétidos Poliéteres
Descriptor policétidos poliéter
Entry term(s) antibióticos poliéter
antibióticos poliéter ionóforos
ionóforos poliéter
poliéteres en escalera marinos
Scope note: Policétidos policíclicos con múltiples motivos poliéter característicos con forma de escalera. En STREPTOMYCES, las policétido-sintasas modulares de tipo I ensamblan esqueletos de policétidos policíclicos que, a su vez, son modificados por epoxidasas y epóxido-hidrolasas para conseguir su estereoquímica. Los antibióticos poliéter ionóforos coordinan cationes metálicos alcalinos con sus múltiples átomos de oxígeno, lo cual altera el gradiente de concentración sodio/potasio. Se utilizan frecuentemente para tratar y controlar la COCCIDIOSIS. Los POLIÉTERES EN ESCALERA MARINOS, estructuralmente relacionados, son neurotoxinas.
Descriptor Portuguese: Policetídeos de Poliéter
Descriptor French: Without translation
Entry term(s): Marine Ladder Polyethers
Polyether Antibiotics
Polyether Ionophore Antibiotics
Polyether Ionophores
Tree number(s): D02.355.291.933
D02.540.576.625
D04.345.241.654
D04.345.674.625
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000095662
Scope note: Polycyclic polyketides with distinctive ladder shaped multiple polyether motifs. In STREPTOMYCES polycyclic polyketide backbones are assembled by type I modular polyketide synthases which then are modified by epoxidase and epoxide hydrolase to achieve their stereochemistry. Polyether ionophore antibiotics coordinate alkali metal cations with their multiple oxygen atoms which disturbs sodium/potassium concentration gradient. They are widely used to treat and control COCCIDIOSIS. Structurally related MARINE LADDER POLYETHERS are neurotoxins.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Public MeSH Note: 2024
History Note: 2024
DeCS ID: 60436
Unique ID: D000095662
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2024/01/01
Date of Entry: 2023/07/26
Revision Date: 2023/02/26
Polyether Polyketides - Preferred
Concept UI M000758735
Scope note Polycyclic polyketides with distinctive ladder shaped multiple polyether motifs. In STREPTOMYCES polycyclic polyketide backbones are assembled by type I modular polyketide synthases which then are modified by epoxidase and epoxide hydrolase to achieve their stereochemistry. Polyether ionophore antibiotics coordinate alkali metal cations with their multiple oxygen atoms which disturbs sodium/potassium concentration gradient. They are widely used to treat and control COCCIDIOSIS. Structurally related MARINE LADDER POLYETHERS are neurotoxins.
Preferred term Polyether Polyketides
Polyether Antibiotics - Narrower
Concept UI M000758734
Preferred term Polyether Antibiotics
Entry term(s) Polyether Ionophore Antibiotics
Polyether Ionophores
Marine Ladder Polyethers - Narrower
Concept UI M000758795
Preferred term Marine Ladder Polyethers



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