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Descriptor English: Eflornithine
Descriptor Spanish: Eflornitina
Descriptor eflornitina
Entry term(s) alfa-difluorometilornitina
difluorometilornitina
Scope note: Inhibidor de la ORNITINA DESCARBOXILASA, la enzima limitante de la velocidad en la vía biosintética de las poliaminas.
Descriptor Portuguese: Eflornitina
Descriptor French: Eflornithine
Entry term(s): DL alpha Difluoromethylornithine
DL-alpha-Difluoromethylornithine
Difluoromethylornithine
Eflornithine Hydrochloride
Eflornithine Monohydrochloride, Monohydrate
MDL 71,782 A
MDL-71,782 A
MDL71,782 A
Ornidyl
Ornithine, alpha-Difluoromethyl
RMI 71782
Vaniqa
alpha Difluoromethyl Ornithine
alpha Difluoromethylornithine
alpha-Difluoromethyl Ornithine
alpha-Difluoromethylornithine
Tree number(s): D12.125.068.665.340
D12.125.095.765.340
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000518
Scope note: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents
Trypanocidal Agents
Ornithine Decarboxylase Inhibitors
Registry Number: ZQN1G5V6SR
CAS Type 1 Name: Ornithine, 2-(difluoromethyl)-
Previous Indexing: Ornithine (1966-1974)
Ornithine/analogs & derivatives (1975-1986)
Public MeSH Note: 1991; see ALPHA-DIFLUOROMETHYLORNITHINE 1987-1990
History Note: 1991; use ALPHA-DIFLUOROMETHYLORNITHINE 1987-1990
DeCS ID: 29232
Unique ID: D000518
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1986/06/03
Revision Date: 2018/05/21
Eflornithine - Preferred
Concept UI M0000787
Scope note An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
Preferred term Eflornithine
Entry term(s) DL alpha Difluoromethylornithine
DL-alpha-Difluoromethylornithine
Difluoromethylornithine
Ornithine, alpha-Difluoromethyl
alpha Difluoromethyl Ornithine
alpha Difluoromethylornithine
alpha-Difluoromethyl Ornithine
alpha-Difluoromethylornithine
MDL-71,782 A - Narrower
Concept UI M0000789
Preferred term MDL-71,782 A
Entry term(s) MDL 71,782 A
MDL71,782 A
Ornidyl - Narrower
Concept UI M0000788
Preferred term Ornidyl
Vaniqa - Narrower
Concept UI M0485299
Preferred term Vaniqa
Eflornithine Monohydrochloride, Monohydrate - Narrower
Concept UI M000638396
Preferred term Eflornithine Monohydrochloride, Monohydrate
Eflornithine Hydrochloride - Narrower
Concept UI M0330745
Preferred term Eflornithine Hydrochloride
RMI 71782 - Narrower
Concept UI M0373515
Preferred term RMI 71782



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